Faculty Information - Seigo Terawaki

（Last updated : 2025-07-14 14:36:06）

Seigo Terawaki
Department Kawasaki Medical School Kawasaki Medical School, Department of Molecular and Genetic Medicine,

Position Assistant Professor with Special Assignment

■ Current specialization

Immunology, Cell biology, Pathological biochemistry (Key Word：immune response, antigen presentation, autophagy, membrane trafficking, vesicle transport)

■ Journal Articles

1.	2025/06	Cellular Lyso-Gb3 Is a Biomarker for Mucolipidosis II.
2.	2024/03	Impaired lysosomal acidity maintenance in acid lipase-deficient cells leads to defective autophagy
3.	2024/01/09	A case series of Fabry diseases with CKD in Japan.
4.	2023/10	HOPS, CORVET and newly-identified Hybrid tethering complexes contribute differentially towards multiple modes of endocytosis.
5.	2023/08	Prenatal Diagnosis of Mucopolysaccharidosis-Plus Syndrome (MPSPS).
6.	2023/03	A Case of Mucopolysaccharidosis II Caused by a Novel Variant with Skin Linear Hyperpigmented Streaks along Blaschko's Lines.
7.	2023/01/16	Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer's disease and amyotrophic lateral sclerosis
8.	2022/08/03	Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43
9.	2022/07/25	A novel nonsense variant in ARID1B causing simultaneous RNA decay and exon skipping is associated with Coffin-Siris syndrome.
10.	2022/06	PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy.
11.	2022/05	Hematopoietic Disorders, Renal Impairment and Growth in Mucopolysaccharidosis-Plus Syndrome.
12.	2021/07	RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages.
13.	2021/05	Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice.
14.	2021/03/19	Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.
15.	2021/03/04	Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling.
16.	2020/10	LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
17.	2020/04	Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
18.	2016/07/13	RUFY4: Immunity piggybacking on autophagy?
19.	2015/10	Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS).
20.	2015/09	RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.
21.	2015/01	PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.
22.	2012/03	Autophagy inhibition promotes defective neosynthesized proteins storage in ALIS, and induces redirection toward proteasome processing and MHCI-restricted presentation.
23.	2012/02	Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells.
24.	2011/03	IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.
25.	2009/06	PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.
26.	2009/05	Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice.
27.	2007/07	Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function.
28.	2005/02	PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
29.	2003/07	PD-1 inhibits antiviral immunity at the effector phase in the liver.
30.	2002/07	Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells.
31.	2001/10	Nasal administration of cholera toxin (CT) suppresses clinical signs of experimental autoimmune encephalomyelitis (EAE).
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■ Presentations

1.	2024/11/08	Impaired lysosomal acidity maintenance in acid lipase-deficient cells leads to defective autophagy （Speech，Panelist at Symposium/Workshop (Applied)）
2.	2022/11/10	The inhibition of LUBAC mitigates amyotrophic lateral sclerosis-associated TDP-43 aggregation （Poster notice，Panelist at Symposium/Workshop (Applied)）
3.	2021/12/02	LUBAC ubiquitin ligase complex and linear ubiquitination facilitate cytoplasmic aggregation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 （Speech，Panelist at Symposium/Workshop (Appointed)）
4.	2021/11/19	HOIPIN-8, a chemical inhibitor for linear ubiquitination, suppresses ALS-related TDP-43 aggregation and inflammatory responses in neuronal cells （Speech，General）
5.	2020/09/17	Macrophages produce histamine through the interaction with antigen specific Th2 cells. （Poster notice，General）
6.	2020/06/06	Macrophages produce histamine through the interaction with antigen-specific Th2 cells. （Speech，General）
7.	2019/05/01	HOIPIN-1, a novel LUBAC inhibitor, suppresses the imiquimod-induced psoriasis-like skin inflammation in mice （Poster notice，Panelist at Symposium/Workshop (Applied)）
8.	2016/08	tRNAs: new regulators of immunity? （Speech，Panelist at Symposium/Workshop (Applied)）
9.	2015/11	Enhanced clearance of intracellular bacterium in IL-4 differentiated dendritic cells. （Poster notice，Panelist at Symposium/Workshop (Applied)）
10.	2014/12/11	Reactivation of autophagy in LPS-stimulated mouse dendritic cells by IL-4 promotes endogenous antigen presentation on MHC class II. （Speech，Panelist at Symposium/Workshop (Appointed)）
11.	2013/10/15	Controlling autophagy through IL-4 signaling in Dendritic Cells. （Speech，Panelist at Symposium/Workshop (Appointed)）
12.	2012/12/04	Regulation of autophagy and endogenous MHC II presentation by TLR signaling in dendritic cells. （Poster notice，Panelist at Symposium/Workshop (Other)）
13.	2006/02/04	Preparation of soluble PD-1 and PD-L1 proteins for blockade of PD-1 signals for application to tumor immunotherapy. （Poster notice，Panelist at Symposium/Workshop (Other)）
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■ Professional Organizations

1.	2001/04～	Japanese Society for Immunology
2.	2018/05～	The Molecular Biology Society of Japan