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(最終更新日:2024-09-05 09:13:14)
テラワキ セイゴウ
Seigo Terawaki
寺脇 正剛
所属
川崎医科大学 医学部 基礎医学 分子遺伝医学
職種
特任講師
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現在の専門分野
免疫学, 細胞生物学, 病態医化学 (キーワード:免疫応答、抗原提示、炎症、オートファジー、メンブレントラフィッキング、小胞輸送)
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著書
1.
2024/05/01
部分執筆
ライソゾーム・オートファジー系の異常症「特集 ライソゾーム病2024」
2.
2023/10/20
部分執筆
ライソゾームの機能と取り込み機序「ライソゾーム病-最新の病態、診断、治療の進歩-(改訂第2版)」
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学術雑誌
1.
2024/03
原著
Impaired lysosomal acidity maintenance in acid lipase-deficient cells leads to defective autophagy
2.
2024/01/09
原著
A case series of Fabry diseases with CKD in Japan.
3.
2023/10/31
原著
HOPS, CORVET and newly‑identified Hybrid tethering complexes contribute differentially towards multiple modes of endocytosis
4.
2023/08
症例報告
Prenatal Diagnosis of Mucopolysaccharidosis-Plus Syndrome (MPSPS).
5.
2023/03/15
症例報告
A Case of Mucopolysaccharidosis II Caused by a Novel Variant with Skin Linear Hyperpigmented Streaks along Blaschko's Lines.
6.
2023/01/16
原著
Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer's disease and amyotrophic lateral sclerosis
7.
2022/08/03
原著
Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43
8.
2022/07/25
原著
A novel nonsense variant in
ARID1B
causing simultaneous RNA decay and exon skipping is associated with Coffin-Siris syndrome.
9.
2022/06
原著
PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy.
10.
2022/05
原著
Hematopoietic Disorders, Renal Impairment and Growth in Mucopolysaccharidosis-Plus Syndrome.
11.
2021/07
原著
RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages.
12.
2021/05
原著
Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice.
13.
2021/03/04
原著
Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling.
14.
2021/03/19
原著
Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.
15.
2020/10
原著
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
16.
2020/04
原著
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
17.
2016/07/13
総説
RUFY4: Immunity piggybacking on autophagy?
18.
2015/10
原著
Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS).
19.
2015/09
原著
RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.
20.
2015/01
原著
PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.
21.
2012/03
原著
Autophagy inhibition promotes defective neosynthesized proteins storage in ALIS, and induces redirection toward proteasome processing and MHCI-restricted presentation.
22.
2012/02
原著
Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells.
23.
2011/03
原著
IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.
24.
2000/11
総説
B細胞 新しい粘膜免疫誘導システムの存在 腸管におけるB-1細胞からのIgA産生
25.
2000/11
総説
【粘膜免疫 21世紀への旅立ち】CMIS独立B-1細胞によるIgA誘導系の存在
26.
2019/12
その他
オートファジーによる免疫応答制御機構の解明
27.
2009/06
原著
PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.
28.
2009/05
原著
Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice.
29.
2007/07
原著
Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function.
30.
2005/02
原著
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
31.
2003/07
原著
PD-1 inhibits antiviral immunity at the effector phase in the liver.
32.
2002/07
原著
Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells.
33.
2001/10
原著
Nasal administration of cholera toxin (CT) suppresses clinical signs of experimental autoimmune encephalomyelitis (EAE).
5件表示
全件表示(33件)
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学会発表
1.
2022/11/10
The inhibition of LUBAC mitigates amyotrophic lateral sclerosis-associated TDP-43 aggregation (ポスター掲示,シンポジウム・ワークショップ パネル(公募))
2.
2022/06/28
直鎖状ユビキチン鎖生成酵素を標的とした阻害剤開発と疾患治療薬としての基礎検討 (口頭,シンポジウム・ワークショップ パネル(公募))
3.
2021/12/02
LUBACユビキチンリガーゼと直鎖状ユビキチン鎖が筋萎縮性側索硬化症関連タンパク質TDP-43の細胞質内凝集形成を促進する (口頭,シンポジウム・ワークショップ パネル(指名))
4.
2021/11/19
HOIPIN-8, a chemical inhibitor for linear ubiquitination, suppresses ALS-related TDP-43 aggregation and inflammatory responses in neuronal cells (口頭,一般)
5.
2020/10/01
抗原特異的Th2細胞による新規ヒスタミン産生機構の解明 (口頭,一般)
6.
2020/09/17
Macrophages produce histamine through the interaction with antigen specific Th2 cells. (ポスター掲示,一般)
7.
2020/09/14
NDP52のユビキチン結合性を介した炎症応答・細胞死制御とLUBAC阻害剤の影響 (ポスター掲示,一般)
8.
2020/06/06
Macrophages produce histamine through the interaction with antigen-specific Th2 cells. (口頭,一般)
9.
2019/05/01
HOIPIN-1, a novel LUBAC inhibitor, suppresses the imiquimod-induced psoriasis-like skin inflammation in mice (ポスター掲示,シンポジウム・ワークショップ パネル(公募))
10.
2015/11
Enhanced clearance of intracellular bacterium in IL-4 differentiated dendritic cells. (ポスター掲示,シンポジウム・ワークショップ パネル(公募))
11.
2014/12/11
Reactivation of autophagy in LPS-stimulated mouse dendritic cells by IL-4 promotes endogenous antigen presentation on MHC class II. (口頭,シンポジウム・ワークショップ パネル(指名))
12.
2013/10/15
Controlling autophagy through IL-4 signaling in Dendritic Cells. (口頭,シンポジウム・ワークショップ パネル(指名))
13.
2012/12/04
Regulation of autophagy and endogenous MHC II presentation by TLR signaling in dendritic cells. (ポスター掲示,シンポジウム・ワークショップ パネル(その他))
14.
2006/02/04
Preparation of soluble PD-1 and PD-L1 proteins for blockade of PD-1 signals for application to tumor immunotherapy. (ポスター掲示,シンポジウム・ワークショップ パネル(その他))
5件表示
全件表示(14件)
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所属学会
1.
2001/04~
日本免疫学会
2.
2018/05~
日本分子生物学会
3.
2023/09~
日本先天代謝異常学会