Present specialized field
（Last updated : 2022-08-19 13:12:19）
Kawasaki Medical School, Department of Molecular and Genetic Medicine,
Assistant Professor with Special Assignment
Present specialized field
Immunology, Cell biology, Pathological biochemistry (Key Word：immune response, antigen presentation, autophagy, membrane trafficking, vesicle transport)
Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43
A novel nonsense variant in ARID1B causing simultaneous RNA decay and exon skipping is associated with Coffin-Siris syndrome.
PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy.
Hematopoietic Disorders, Renal Impairment and Growth in Mucopolysaccharidosis-Plus Syndrome.
RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages.
Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice.
Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.
Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling.
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
RUFY4: Immunity piggybacking on autophagy?
Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS).
RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.
PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.
Autophagy inhibition promotes defective neosynthesized proteins storage in ALIS, and induces redirection toward proteasome processing and MHCI-restricted presentation.
Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells.
IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.
PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.
Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice.
Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function.
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
PD-1 inhibits antiviral immunity at the effector phase in the liver.
Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells.
Nasal administration of cholera toxin (CT) suppresses clinical signs of experimental autoimmune encephalomyelitis (EAE).
Display 5 items
LUBAC ubiquitin ligase complex and linear ubiquitination facilitate cytoplasmic aggregation of amyotrophic lateral sclerosis (ALS)-associated TDP-43
HOIPIN-8, a chemical inhibitor for linear ubiquitination, suppresses ALS-related TDP-43 aggregation and inflammatory responses in neuronal cells
Macrophages produce histamine through the interaction with antigen specific Th2 cells.
Macrophages produce histamine through the interaction with antigen-specific Th2 cells.
HOIPIN-1, a novel LUBAC inhibitor, suppresses the imiquimod-induced psoriasis-like skin inflammation in mice
Japanese Society for Immunology
The Molecular Biology Society of Japan
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