教員情報 - 寺脇　正剛

現在の専門分野

学術雑誌

学会発表

所属学会

（最終更新日：2023-02-03 20:35:30）

  テラワキ　セイゴウ   Seigo Terawaki
  寺脇　正剛
   所属   川崎医科大学医学部基礎医学　分子遺伝医学

職種特任講師

■ 現在の専門分野

免疫学, 細胞生物学, 病態医化学　（キーワード：免疫応答、抗原提示、炎症、オートファジー、メンブレントラフィッキング、小胞輸送）

■ 学術雑誌

1.	2000/11	総説	B細胞　新しい粘膜免疫誘導システムの存在　腸管におけるB-1細胞からのIgA産生
2.	2000/11	総説	【粘膜免疫　21世紀への旅立ち】CMIS独立B-1細胞によるIgA誘導系の存在
3.	2019/12	その他	オートファジーによる免疫応答制御機構の解明
4.	2023/01/16	原著	Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer's disease and amyotrophic lateral sclerosis
5.	2022/08/03	原著	Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43
6.	2022/07/25	原著	A novel nonsense variant in ARID1B causing simultaneous RNA decay and exon skipping is associated with Coffin-Siris syndrome.
7.	2022/06	原著	PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy.
8.	2022/05	原著	Hematopoietic Disorders, Renal Impairment and Growth in Mucopolysaccharidosis-Plus Syndrome.
9.	2021/07	原著	RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages.
10.	2021/05	原著	Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice.
11.	2021	原著	Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.
12.	2021	原著	Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling.
13.	2020/10	原著	LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
14.	2020/04	原著	Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
15.	2016	総説	RUFY4: Immunity piggybacking on autophagy?
16.	2015/10	原著	Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS).
17.	2015/09	原著	RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.
18.	2015/01	原著	PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.
19.	2012/03	原著	Autophagy inhibition promotes defective neosynthesized proteins storage in ALIS, and induces redirection toward proteasome processing and MHCI-restricted presentation.
20.	2012/02	原著	Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells.
21.	2011/03	原著	IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.
22.	2009/06	原著	PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.
23.	2009/05	原著	Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice.
24.	2007/07	原著	Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function.
25.	2005/02	原著	PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
26.	2003/07	原著	PD-1 inhibits antiviral immunity at the effector phase in the liver.
27.	2002/07	原著	Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells.
28.	2001/10	原著	Nasal administration of cholera toxin (CT) suppresses clinical signs of experimental autoimmune encephalomyelitis (EAE).
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■ 学会発表

1.	2021/12/02	LUBACユビキチンリガーゼと直鎖状ユビキチン鎖が筋萎縮性側索硬化症関連タンパク質TDP-43の細胞質内凝集形成を促進する（口頭発表，シンポジウム・ワークショップ・パネルディスカッション等）
2.	2021/11/19	HOIPIN-8, a chemical inhibitor for linear ubiquitination, suppresses ALS-related TDP-43 aggregation and inflammatory responses in neuronal cells （口頭発表，一般）
3.	2020/10/01	抗原特異的Th2細胞による新規ヒスタミン産生機構の解明（口頭発表，一般）
4.	2020/09/17	Macrophages produce histamine through the interaction with antigen specific Th2 cells. （ポスター，一般）
5.	2020/09/14	NDP52のユビキチン結合性を介した炎症応答・細胞死制御とLUBAC阻害剤の影響（ポスター，一般）
6.	2020/06/06	Macrophages produce histamine through the interaction with antigen-specific Th2 cells. （口頭発表，一般）
7.	2019/05/01	HOIPIN-1, a novel LUBAC inhibitor, suppresses the imiquimod-induced psoriasis-like skin inflammation in mice （ポスター，シンポジウム・ワークショップ・パネルディスカッション等）
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■ 所属学会

1.	2001/04～	日本免疫学会
2.	2018/05～	日本分子生物学会