Faculty Information - Katsuhiko Ishihara

（Last updated : 2025-03-31 18:33:54）

Katsuhiko Ishihara
Department Kawasaki University of Medical Welfare ,

Position Professor with Special Assignment

■ BooK

1.	2012/01	Molecular mechanisms of rheumatoid arthritis revealed by categorizing subtypes of fibroblast-like synoviocytes., Rheumatoid Arthritis – Etiology, and Consequences and Co-morbidities
2.	2002	Analysis of human CD157 by means of murine mAbs., Leucocyte Typing VII
3.	1997	CD157(BST-1)workshop panel report, Leucocyte typing VI

■ Journal

1.	2024/02/01	Bone marrow stromal cell antigen-1 deficiency protects from acute kidney injury.
2.	2023/06/23	Revisiting immunological roles for bone marrow stromal cell antigen-1; an entero-neuro-immune regulator.
3.	2021/11/19	BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
4.	2020/12/16	Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging
5.	2020/12/10	Senescent cells promote tissue NAD⁺ decline during ageing via the activation of CD38⁺ macrophages.
6.	2020/06/22	Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder.
7.	2019/08	CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production.
8.	2019/08	Functional analysis of a novel G87V TNFRSF1A mutation in patients with TNF receptor-associated periodic syndrome
9.	2019/06	IL-6-PAD4 axis in the earliest phase of arthritis in knock-in gp130F759 mice, a model for rheumatoid arthritis
10.	2019/04	Sh3bp2 Gain-Of-Function Mutation Ameliorates Lupus Phenotypes in B6.MRL-Fas^lpr Mice.
11.	2018/06	Possible Involvement of the Dopaminergic System in Emotional Deficiency in CD157/BST1Knockout Mice.
12.	2018/03	CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties.
13.	2017/05	Communication impairment in ultrasonic vocal repertoire during the suckling period of Cd157 knockout mice: transient improvement by oxytocin
14.	2017/05	Selegiline ameliorates depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's diseases.
15.	2017/03	An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator.
16.	2015/12	TNF receptor type 2 transmits caspase-dependent apoptotic signals in fibroblast-like synoviocytes derived from rheumatoid arthritis
17.	2015/01	Lipo-oxytocin-1, A Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-lasting Effects on Anxiety-related Behavior and Social Avoidance in CD157 Knockout Mice.
18.	2014/12	History and perspectives of research in Bone marrow stromal cell antigen -1(BST-1)/CD157:A relatives of ADP-ribosyl cyclase CD38.
19.	2014/10	Infection-Immunity Liaison: Pathogen-driven autoimmune-mimicry (PDAIM).
20.	2014/04	Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease.
21.	2014/01	Anti-apoptotic roles for the mutant p53R248Q through suppression of p53-regulated apoptosis-inducing protein 1 in the RA-derived fibroblast-like synoviocyte cell line MH7A.
22.	2013/01	Displays of paternal mouse pup retrieval following communicative interaction with maternal mates.
23.	2012/01	A pro-inflammatory role for A20 and ABIN family proteins in human fibroblast-like synoviocytes in rheumatoid arthritis.
24.	2010	TP53 mutations coincide with the ectopic expression of activation-induced cytidine deaminase in the fibroblast-like synoviocytes derived from a fraction of patients with rheumatoid arthritis.
25.	2009/02	Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice.
26.	2008/04	IL-6 directly inhibits osteoclast differentiation by suppressing rank signaling pathways.
27.	2008/01	Reduced alpha4beta1 integrin/VCAM-1 interactions lead to impaired pre-B cell repopulation in alpha 1,6-fucosyltransferase deficient mice.
28.	2007/06	IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state.
29.	2007/05	Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model.
30.	2007	Gab2 plays distinct roles in bone homeostasis at different time points.
31.	2006/09	A critical role for interleukin-6 family-mediated Stat3 activation in osteoblast differentiation and bone formation.
32.	2006/06	Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells.
33.	2006	TRIF-GEFH1- RhoB cascade regulates surface expression of MHC class II in dendritic cells that is critical for CD4+ T cell activation.
34.	2005/11	Hyperactivation of gp130-mediated STAT3 signaling induces a rheumatoid arthritis-like disease that is dependent on MHC class II restricted CD4+ T cells.
35.	2005/11	IL-6-STAT3 controls intracellular MHC classII ab-dimer level through Cathepsin S activity in dendritic cells
36.	2004/11	Evidence of a novel IL-2/15Rbeta-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells.
37.	2004/10	Development of CD4+ Macrophages from Intrathymic T Cell Progenitors Is Induced by Thymic Epithelial Cells
38.	2004/09	IL-6 Regulates in vivo Dendritic Cell Differentiation through STAT3 Activation
39.	2004/09	Roles of MITF for Development of Mast Cells in Mice: Effects on Both Precursors and Tissue Environments.
40.	2004/06	Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina.
41.	2004/03	The point mutation of Y759 of the IL-6 family receptor gp130 synergizes with HTLV-1 pX in promoting RA-like arthritis.
42.	2003	IL-6 signal transduction and its physiological roles:The signal orchestration model
43.	2002	A point mutation of Tyr-759 in interleukin 6 family cytokine rreceptor subunit gp130 causes autoimmune arthritis
44.	2002	Adapter molecule Gabl is specifically expressed in marginal zone B cells and negatibely regulates TI-2 responses &0d0a;
45.	2002	Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase actibities;
46.	2002	GATA-2/estrogen receptor chimera regulates cytokine-dependen growth of hematopoietic cells through accumulation of p21WAFl and p27Kipl proteins;
47.	2002	IL-6 in autoimmune disease and chronic inflammatory proliferative disease
48.	2002	Requirement of Gab2 for mast cell development and Kitl/c-Kit signaling;
49.	2002	The molecular basis of the cell-specificity of cytokine action
50.	2002	Tyrosine 759 of the cytokine receptor gp130 is involved in Listeria monocytogenes susceptibility ;
51.	2001	Site-directed removal of N-glycosilation sites in BST-1/CD157 : effects on molecular and functional heterogeneity
52.	2001	Tissue-specific autoregulation of the stat3 gene and its role in interleukin 6-induced survival singnals in T cells. &0d0a;
53.	2000	BST-1/CD157 regulates the humoral immune responses in vivo.
54.	2000	Dissection of signaling cascades through gp130 in vivo : Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.(共著)
55.	2000	gp130-mediated signalings as therapeutic targets.
56.	2000	Roles of STAT3 in mediating the cell growth, differentiation, and survival signals relayed through the IL-6 family of cytokine receptors.
57.	1999	Gab-family adaptor protein act downstream of cytokine and growth factor receptors and T-and B-cell antigen receptors.
58.	1999	Nobel peptide inhibitor of ecto-ADP-ribosy1 cyclase of bone marrow stromal cell antigen-1(BST-1/CD157)
59.	1998	Deletion of bone marrow stromal cell antigen-1(CD157)gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses(共著)
60.	1998	Nurse-like cells from bone marrow and synovium of patients with rheumatoid arthritis promote survival and enhance function of human B cells.
61.	1997	CD79α/CD79β heterodimers are expressed on pro-B cell surfaces without associated μ heavy chain(共著)
62.	1996	Elevated levels of the Soluble form of bone marrow stromal cell antigen-1 (BST-1) in the sera of patients with severe rheumatoid arthritis.
63.	1996	Genomic structure of human BST-1.
64.	1996	Human BST-1 expressed on myeloid cells functions as a receptor molecule.
65.	1996	Pancreatic lslet Cells Express BST-1, a CD38-like Surface Molecule Having ADP-Ribosyl Cyclase Activity.
66.	1996	Stage specific expression of mouse BST-1/BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor.
67.	1995	Molecular Cloning and Chromosomal Mapping of a Bone Marrow Stromal Cell Surface Gene, BST2, That May Be Involved in Pre-B-Cell Growth.
68.	1994	ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule BST-1.
69.	1994	Inductuion of programmed cell death in human hematopoietic cell lines by fibronectin via its interaction with very late antigen 5.
70.	1994	Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase.
71.	1994	T cell abnormalities in mixed connective tissue complicated with Klinefelter's syndrome.
72.	1993	CD44 and other cell interaction molecules contributing to B lymphopoiesis.
73.	1993	Multiple B29 containing complexes on murine B lymphocytes. Common and stage-restricted Ig-associated polypeptide chains.
74.	1992	B29 gene products complex with immunoglobulins on B lymphocytes.
75.	1992	Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition.
76.	1991	A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binbing of lyphocyte precursors in culture.
77.	1991	Stromal-cell and cytokine-dependent lymphocyte clones which span the pre-B-to B-cell transition.
78.	1990	B-B cell interaction involved in polyclonal B cell activation is restricted by I-A but not I-E molecules.
79.	1990	Involvement of I-A-restricted B-B cell interaction in the polyclonal B cell differentiation induced by lipopolysaccharide.
80.	1989	Cluster formation among small resting Blymphocytes leading to B cell activation.
81.	1989	Different effect of prostaglandin E2 on B-cell activation by two distinct B-cell differentiation factors, B151-TRF1/IL-5 and B151-TRF2 : selective inhibition ofB151-TRF2-induced antibody response through increases in inteacellular cyclic AMP levels.
82.	1989	Disparate function of I-A and I-E molecules on B cells as evidenced by the inhibition with anti-I-A and anti-E antibodies of polyclonal B cell activation.
83.	1989	Type II collagen-induced murine arthritis. II. Genetic control of arthritis induction is expressed on L3T4+ T cells required for humoral as well as cell mediated immune responses to type II collagen.
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■ Presentation

1.	2022/12/08	Single-cell RNA-sequencing of the synovial cells in gp130F759, a murine rheumatoid arthritis model, revealed changes in B-cell repertoire at the transitional phase from innate to acquired immunity （Poster notice，Panelist at Symposium/Workshop (Applied)）
2.	2021/12/09	Pro-inflammatory roles for bone marrow stromal cell antigen-1 (BST-1)/CD157 in colitis induced by dextran sodium sulfate (DSS) （Poster notice，Panelist at Symposium/Workshop (Applied)）
3.	2021/12/09	Single-cell RNA-sequencing of the synovium in gp130F759, a murine rheumatoid arthritis model, at the transitional phase from innate to acquired immunity （Poster notice，Panelist at Symposium/Workshop (Applied)）
4.	2021/05/10	Lack of bone marrow stromal cell antigen-1 (BST-1)/CD157 ameliorated colitis induced by dextran sodium sulfate (DSS) （Poster notice，General）
5.	2020/10/24	SH3BP2 deficiency ameliorates murine systemic lupus erythematosus （Poster notice，General）
6.	2020/08/17	IL-6-PAD4 axis in the preclinical state of the synovium in gp130F759 -interaction between fibroblast-like synoviocytes and neutrophils- （Speech，General）
7.	2020/07/08	全身性エリテマトーデスモデルマウスにおけるアダプター蛋白SH3BP2 の自己免疫現象における役割の解明（Poster notice，General）
8.	2019/12/13	IL-6-PAD4 axis: IL-6 dependent PAD4 production in neutrophils at the earliest phase of arthritis in gp130F759. （Poster notice，General）
9.	2019/12/11	Toll-like receptor-induced Ab production from marginal zone B cells is negatively regulated by ADP-ribosyl cyclase BST-1/CD157 （Poster notice，General）
10.	2019/11/10	The Study of the Novel G87V Mutation in the TNFRSF1A Gene Identified in a Family with TNF Receptor-Associated Periodic Syndrome (TRAPS) （Poster notice，General）
11.	2019/06/06	CX3CR1-eGFP⁺ macrophage-like synoviocytes in gp130F759, a mouse model for rheumatoid arthritis （Poster notice，General）
12.	2019/04/17	SH3BP2 gain-of-function mutation ameliorates lupus in B6.MRL-Faslpr mice （Speech，General）
13.	2018/12/12	BST-1/CD157 negatively regulates marginal zone B cell survival and Ab production induced with Toll-like receptor stimulation （Poster notice，General）
14.	2018/12/12	Deletion of padi4 exacerbated the arthritis in gp130F759. （Poster notice，General）
15.	2018/12/11	Elongation of the small intestine and enlargement of the mesenteric lymph nodes in Bst1Cd38 double knockout mice. （Poster notice，General）
16.	2018/05/06	A novel function of ADP-ribosyl cyclases to regulate the length of the small intestine revealed in CD38/CD157 double knockout mice （Speech，General）
17.	2018/05/04	Accelerated onset of arthritis by systemic infection of Mycoplasma fermentans in the knock-in mice gp130F759 （Poster notice，General）
18.	2017/12/12	BST-1/CD157 on B cells negatively regulates Toll-like receptor signaling （Poster notice，General）
19.	2017/11/07	SH3BP2 Gain-of-Function Mutation Ameliorates Lupus in B6.MRL-Faslpr Mice （Poster notice，General）
20.	2017/11/04	Bone Marrow Stromal Cell Antigen-1 Identified by RNA-Seq and ChIP-Seq Is important for Inducing Renal Ischemia-Reperfusion Injury and Fibrosis （Speech，General）
21.	2016/12/06	Padi4 expression by neutrophils in the synovium appears in the earliest phase of arthritis in gp130F759 （Poster notice，General）
22.	2016/12/05	Lack of microbiota revealed the role for BST-1/CD157 to maintain the homeostasis at mucosa-MLN interface （Poster notice，General）
23.	2016/11/21	Systemic infection with Mycoplasma fermentans facilitates development of arthritis in the knock-in mice gp130F759 through the action of neutrophils. （Poster notice，General）
24.	2015/12/20	Enhanced TI-1 antigen responses in BST-1/CD157 knock-out mice of C57BL/6J background （Poster notice，Panelist at Symposium/Workshop (Applied)）
25.	2015/12/19	Critical roles of neutrophils for development of arthritis in the knock-in mouse gp130F759 induced by systemic infection of Mycoplasma fermentans （Poster notice，Panelist at Symposium/Workshop (Applied)）
26.	2014/12/11	High density of TNFR2 on fibroblast-like synoviocyte derived from rheumatoid arthritis provides the sensitivity to cell death. （Poster notice，General）
27.	2014/12/11	Increase of neutrophils in the synovia precedes the onset of arthritis induced by infection with Mycoplasma fermentans in the knock-in mouse gp130F759. （Poster notice，General）
28.	2014/12/11	Over-expression of ABIN-3 negatively regulates Erk and Akt activity leading to apoptosis of rheumatoid arthritis-derived fibroblast-like synoviocyte cell line. （Poster notice，General）
29.	2014/11/26	History and perspectives of research in BST-1/CD157 Bone marrow stromal cell antigen-1 (BST-1) A relative of ADP-ribosyl cyclace CD38 （Speech，Panelist at Symposium/Workshop (Appointed)）
30.	2013/12/12	Mycoplasma fermentans facilitates the progress of arthritis in the knock-in mouse gp130F759 （Speech，Panelist at Symposium/Workshop (Applied)）
31.	2013/12/04	Disease-promoting roles for eosinophils in antigen-induced arthritis. （Poster notice，General）
32.	2013/12/04	P53R248Q mutant causes apoptosis-resistant fibroblast-like synoviocyte in RA through suppression of pro-apoptotic molecule p53AIP1. （Poster notice，General）
33.	2013/10/03	p53R248Q mutant suppresses p53AIP1,providing apoptosis-resistance to fibroblast-like synoviocyte in oxidative stress. （Poster notice，General）
34.	2013/08/23	Increase of PADI4 in the joints and anti-CCP antibody in the sera in a murine model for rheumatoid arthritis before the clinical onset of arthritis （Poster notice，General）
35.	2013/07/26	A new web-based lecture evaluation system at Kawasaki Medical School （Poster notice，General）
36.	2012/12/13	Phenotypic analysis of p53-mutants found in the fibroblast-like synoviocytes derived from rheumatoid arthritis with ectopic expression of AID. （Poster notice，General）
37.	2012/12/05	Eosinophils are increased in the synovium of gp130F759 before the clinical onset of srthritis. （Speech，Panelist at Symposium/Workshop (Other)）
38.	2012/12/05	PADI4 gene expression in the joints and serum anti-CCP antibody at very early stage of arthritis in the knock-in mouse gp130F759. （Speech，Panelist at Symposium/Workshop (Other)）
39.	2012/12/05	The functional properties of mutant p53-R248Q found in AID-expressing fibroblast-like synoviocytes from rheumatoid arthritis. （Speech，Panelist at Symposium/Workshop (Other)）
40.	2012/10/23	Increase of inflammatory cells and expression of Padi4 in the joints of the murine rheumatoid arthritis model gp130F759 before the clinical onset of arthritis （Poster notice，General）
41.	2012/10/23	The pro-inflammatory function of A20 and ABINs in a subtype of fibroblast-like synoviocytes derived from rheumatoid arthritis. （Poster notice，General）
42.	2012/09/19	Functional evaluation of p53-mutants in fibroblast-like synoviocytes with ectopic AID expression in rheumatoid arthritis. （Poster notice，General）
43.	2011/12/14	The pro-inflammatory function of A20 and ABINs in a subtype of fibroblast-like synoviocytes derived from rheumatoid arthritis. （Poster notice，General）
44.	2011/11/28	A subtype of fibroblast-like synoviocytes derived from rheumatoid arthritis exhibits a pro-inflammatory phenotype by A20 and ABINs. （Poster notice，General）
45.	2010/08/24	Comparative analysis of gene expression in a subtype of fibroblast-like synoviocytes between rheumatoid arthritis and osteoarthritis （Poster notice，General）
46.	2010/08/24	Deletion of core fucosylation on pre-BCR down-regulates its functions （Poster notice，General）
47.	2010/08/24	Heterogeneity of gene expression profiles in fibroblast-like synoviocytes of rheumatoid arthritis and osteoarthritis （Poster notice，Panelist at Symposium/Workshop (Other)）
48.	2009/12/04	Association of aberrant AID expression with p53 gene somatic mutations in a fraction of synovial fibroblast-like cell lines from RA patient．（Poster notice，General）
49.	2009/12/04	Profiling of genes expressed by subtypes of synovial fibroblast-like cell lines from rheumatoid arthritis and osteoarthritis．（Poster notice，General）
50.	2007/11/21	Search for cell-intrinsic abnormalities of synovial fibroblasts in rheumatoid arthritis. （Poster notice，Panelist at Symposium/Workshop (Other)）
51.	2006/12/13	IL-6/IL-6 family-STAT3-IL-7 cascade causes an autoimmune arthritis via CD4+ T-cell homeostatic proliferation in gp130F759/F759 mice （Speech，Panelist at Symposium/Workshop (Other)）
52.	2006/12/13	The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 enhances the severity of collagen-induced arthritis in DBA/1J mice （Poster notice，Panelist at Symposium/Workshop (Other)）
53.	2006/12/12	Impaired early B cell development in the a1,6-fucosyltransferase deficient mice （Poster notice，Panelist at Symposium/Workshop (Other)）
54.	2006/12/11	A mutant mouse having excess amount of memory T cells is a model mouse of Omenn syndrome （Speech，Panelist at Symposium/Workshop (Other)）
55.	2006/11/12	The Point Mutation of Tyrosine 759 Of The IL-6 Family Cytokine Receptor Gp130 Augments Collagen-Induced Arthritis in DBA/1J Mice （Poster notice，General）
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■ Belonging society

2009/06～

the American Association of Immunologists