Faculty Information - Shinichiro Nishimatsu

Present specialized field

BooK

Journal

Presentation

Belonging society

（Last updated : 2026-09-07 16:24:56）

Shinichiro Nishimatsu
Department Kawasaki Medical School Kawasaki Medical School, Department of Natural Sciences,

Position Professor

■ Present specialized field

Functional biochemistry, Molecular biology, Developmental biology

■ BooK

1991/09

Mesoderm induction in early amphibian embryos by activin A and its related gene products in Xenopus laevis, Frontiers in Muscle Research: Myogenesis, Muscle Contraction and Muscle Dystrophy

■ Journal

1.	2026/04/13	Retinoic acid reduces oxidative stress and enhances migration-related signaling in vascular endothelial cells
2.	2026	Learner needs assessment through active learning development: A trial at Kawasaki Senior High School Attached to Kawasaki Medical School
3.	2025/09/04	Comparison of the Anticancer Effects of a Complementary Peptide for Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3) With Conventional Anticancer Drugs in the Treatment of Oral Squamous Cell Carcinoma: A Pilot Study
4.	2025/03/11	NADPH oxidase subunit p22^phox: A marker of oxidase-dependent oxidative stress and target for stress suppression in nonphagocytic cells
5.	2024/10	Risk analysis of transmission sources of Aspiculuris tetraptera in a laboratory animal facility
6.	2023/12	DKK3 expression is correlated with poorer prognosis in head and neck squamous cell carcinoma: A bioinformatics study based on the TCGA database
7.	2023/11	DKK3/CKAP4 axis is associated with advanced stage and poorer prognosis in oral cancer
8.	2023/05	Circulating α-Klotho Counteracts Transforming Growth Factor-β-Induced Sarcopenia.
9.	2023/03/23	Tumor suppressing effects of complementary peptide targeting DKK3 in head and neck squamous cell carcinoma.
10.	2023/02/10	Circulating α-Klotho Counteracts Transforming Growth Factor-β-Induced Sarcopenia
11.	2022/11/15	Establishment of anti-DKK3 peptide for the cancer control in head and neck squamous cell carcinoma (HNSCC).
12.	2022/11	Caveolin 3 suppresses phosphorylation-dependent activation of sarcolemmal nNOS.
13.	2022/10	Maximal Multistage Shuttle Run Test-induced Myalgia in a Patient with Muscle Phosphorylase B Kinase Deficiency.
14.	2022/08/27	Caveolin 3 suppresses phosphorylation-dependent activation of sarcolemmal nNOS
15.	2022/04/15	Maximal Multistage Shuttle Run Test-induced Myalgia in a Patient with Muscle Phosphorylase B Kinase Deficiency
16.	2019/05	Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial.
17.	2019/03	DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways.
18.	2018/08/23	Stem Cell-Induced Pulp Regeneration Can Be Enhanced by Administration of CCL11-Neutralizing Antibody in the Ectopic Tooth Transplantation Model in the Aged Mice.
19.	2018/01	DKK3 Overexpression Increases Malignant Properties of Head and Neck Squamous Cell Carcinoma Cells.
20.	2017/07	Slow-Myofiber Commitment by Semaphorin 3A Secreted from Myogenic Stem Cells.
21.	2017/06	Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice.
22.	2017/04	Establishment of the complete life cycle of Spirometra (Cestoda: Diphyllobothriidae) in the laboratory using a newly isolated triploid clone
23.	2016/03	Erratum to: miR-487b, miR-3963 and miR-6412 delay myogenic differentiation in mouse myoblast-derived C2C12 cells.
24.	2015/04	miR-487b, miR-3963 and miR-6412 delay myogenic differentiation in mouse myoblast-derived C2C12 cells
25.	2014/12	Cell-autonomous signal transduction in the Xenopus egg Wnt/beta-catenin pathway.
26.	2013/06	Interaction of Wnt signaling with BMP/Smad signaling during the transition from cell proliferation to myogenic differentiation in mouse myoblast-derived cells
27.	2012/12	Taurine Ameliorates Impaired the Mitochondrial Function and Prevents Stroke-like Episodes in Patients with MELAS
28.	2012/10	Muscle-specific overexpression of caveolin 3 causes muscle atrophy, but not muscular dystrophy
29.	2012/08	An inhibitor of transforming growth factor beta type I receptor ameliorates muscle atrophy in a mouse model of caveolin 3-deficient muscular dystrophy
30.	2012/05	Strategies to detect interdigital cell death in the frog, Xenopus laevis: T3 accerelation, BMP application, and mesenchymal cell cultivation.
31.	2008/03	VegT, eFGF and Xbra cause overall posteriorization while Xwnt8 causes eye-level restricted posteriorization in synergy with chordin in early Xenopus development.
32.	2007/08	A Wnt3a variant participates in chick apical ectodermal ridge formation: distinct biological activities of Wnt3a splice variants in chick limb development.
33.	2005/06	Wnt10a is involved in AER formation during chick limb development.
34.	2004/07	Expression of Tbx20 RNA during chick heart development.
35.	2004/05	Bone Morphogenetic Protein-3 family members and their biological functions.
36.	2004/05	Cytoplasmic and molecular reconstruction of Xenopus embryos: Synergy of dorsalizing and endo-mesodermalizing determinants drives early axial patterning.
37.	2004/05	Serum amyloid A, C-reactive protein and remnant-like lipoprotein particle cholesterol in type 2 diabetic patients with coronary heart disease.
38.	2003/08	Coordination of BMP-3b and cerberus is required for head formation of Xenopus embryos.
39.	2002/12	Anteroposterior patterning in Xenopus embryos: Egg fragment assay system revealed a synergy of dorsalizing and posteriorizing embryonic domain.
40.	2002/09	Paraquat-induced gene expression in rat lung tissues using a differential display reverse transcription-polymerase chain reaction.
41.	2002/04	A missense mutant myostatin causes hyperplasia without hypertrophy in the mouse muscle.
42.	2002	Comparison of DNA sequences on VZV glycoproteins of the Oka vaccine and parental Oka strains.
43.	2001/12	Expression of bone morphogenetic protein-5 gene during chick heart development: possible roles in valvuloseptal endocardial cushion formation.
44.	2000/12	Involvement of frizzled-10 in Wnt-7a signaling during chick limb development.
45.	2000/03	Identification of chick frizzled-10 expressed in the developing limb and the central nervous system.
46.	1999/07	Differential expression of the frizzled family involved in Wnt signaling during chick limb development.
47.	1999/03	Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus.
48.	1999/02	Involvement of Wnt-5a in chodrogenic pattern formation in the chick limb bud.
49.	1998/06	Ventral mesoderm induction and patterning by bone morphogenetic protein heterodimers in Xenopus embryos.
50.	1996	Heart formative factor(s) is localized in the anterior endoderm of early Xenopus neurula.
51.	1995/08	Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia.
52.	1995/06	Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region.
53.	1995/05	Molecular cloning and functional analysis of a new activin β subunit : a dorsal mesoderm-inducing activity in Xenopus.
54.	1995/03	Expression of BMP-2, 4 genes during early development in Xenopus.
55.	1994/10	Molecular cloning of a gene under control of the circadian clock and light in the rodent SCN.
56.	1994/08	Isolation and characterization of two alternatively spliced complementary DNAs encoding a Xenopus laevis angiotensin II receptor.
57.	1994/03	Autoinduction of activin genes in early Xenopus embryos.
58.	1994/02	Regulation of primary erythropoiesis in the ventral mesoderm of Xenopus gastrula embryo: evidence for the expression of a stimulatory factor(s) in animal pole tissue.
59.	1994	Diurnal regulation of per repeat family in the suprachiasmatic nucleus of rat brain.
60.	1993/04	Biochemical properties of amphibian bone morphogenetic protein-4 expressed in CHO cells.
61.	1993/02	Differential expression of Xenopus BMPs in early embryos and tissues.
62.	1993	Immunodetection of Xenopus bone morphogenetic protein-4 in early embryos.
63.	1992/11	A carboxyl-terminal truncated version of the activin receptor mediates activin signals in early Xenopus embryos.
64.	1992/08	Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos.
65.	1992/05	Multiple genes for Xenopus activin receptor expressed during early embryogenesis.
66.	1992/04	Expression of thymosin beta4 gene during Xenopus laevis embryogenesis.
67.	1992	Identification of bone morphogenetic protein-2 in early Xenopus laevis embryos.
68.	1991/08	Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis.
69.	1990	Activin as a cell differentiation factor.
70.	1988/12	Mouse spleen derived cDNA clones containing per repeat sequence.
71.	1988/04	Mouse hexamer repeat sequences homologous to the Drosophila 'period' gene.
72.	1986	Human renin gene of renin-secreting tumor.
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■ Presentation

1.	2026/09/30	Specific peptides targeting the inhibitory core of myostatin alleviate pathologival phenotypes in dystrophin- and caveolin-3-deficient mice （Poster notice，General）
2.	2026/07/08	A cyclic peptide targeting the myostatin-inhibitory core region alleviates dystrophic pathology in D2-mdx mice （Poster notice，General）
3.	2026/07/08	Specific myostatin inhibition ameliorates sarcopenia and extends lifespan in α-Klotho-null mice （Poster notice，General）
4.	2026/05/22	Myostatin blockade rescues sarcopenia and survival in alpha-Klotho knockout mice （Speech，General）
5.	2026/03/10	Active Learning with AlphaFold: Visualizing Protein Structures in Undergraduate Lecture （Poster notice，General）
6.	2025/10/10	An inhibitory peptide for myostatin alleviates dystrophic pathology in dystrophin-deficient DBA/2-mdx mice （Poster notice，General）
7.	2025/10/10	Blockade of myostatin restores sarcopenia and extends lifespan in alpha-Klotho-deficient senescence-model mice （Poster notice，General）
8.	2025/07/27	Learner needs assessment through active learning development （Poster notice，General）
9.	2025/05/21	Myostatin inhibition restores sarcopenia and extends lifespan in the alpha-Klotho knockout mice （Speech，General）
10.	2025/04/20	Retinoic acid upregulates Nox4-induced redox signal-dependent endothelial cell migration （Poster notice，General）
11.	2024/10/09	Circulating alpha-Klotho combats TGF-beta-induced sarcopenia. （Poster notice，General）
12.	2024/10/09	Stapled inhibitory core peptide of myostatin alleviates dystrophic pathology in dystrophin-deficient DBA/2-mdx mice （Poster notice，General）
13.	2024/09/13	Caveolin 3 inhibits phosphorylation-dependent activation of sarcolemmal nNOS （Speech，General）
14.	2022/05/19	nNOS activation in the pathogenesis of caveolin-3-deficient limb-girdle muscular dystrophy 1C. （Poster notice，General）
15.	2022/05/18	A stapled myostatin inhibitory core peptide: its effect on caveolin-3- or dystrophin-deficient mice. （Speech，General）
16.	2021/05/22	Molecular crosstalk between caveolin 3 and nNOS: implications for Limb-girdle muscular dystrophy 1C （Speech，General）
17.	2021/05/21	Therapeutic effects of an optimized myostatin inhibitory peptide. （Speech，General）
18.	2020/10/01	DKK3 regulates malignant property of head and neck squamous cell carcinoma via phosphorylation of Akt. （Poster notice，General）
19.	2018/08/23	Establishment of a newly isolated triploid clone of Spirometra (Cestoda: Diphyllobothriidae) as a powerful tool for studying the molecular and cellular bases of sparganosis （Speech，General）
20.	2018/03/18	Establishment of the complete life cycle of Spirometra (Cestoda: Diphyllobothriidae) in the laboratory using a newly isolated triploid clone （Speech，General）
21.	2017/11/05	The Effect of Myostatin Inhibition on Bone Loss in Murine Osteoporosis Models （Poster notice，General）
22.	2017/11/05	The effect of myostatin inhibition on bone loss in murine osteoporosis models. （Poster notice，General）
23.	2017/09/20	CAVEOLIN-3 CONTROLS SARCOLEMMAL nNOS ACTIVITY: IMPLICATION IN LIMB-GIRDLE MUSCULAR DYSTROPHY 1C （Poster notice，General）
24.	2017/09/19	The inhibitory core of myostatin prodomain: its suppression of ligand-receptor binding and potential for muscle wasting disorders. （Poster notice，General）
25.	2017/04/27	Knockdown of DKK3 gene reduces malignant properties of oral squamous cell carcinoma-derived cells （Poster notice，General）
26.	2017/04/24	miRNA-mediated crosstalk between Wnt3a and TGFb3 in osteoblast differentiation. （Poster notice，General）
27.	2016/10	MELAS, a first-ever tRNA modification disorder is alleviated by taurine supplimentation therapy （Poster notice，General）
28.	2016/04	Mouse model of muscle atrophy with water-immersion restraint stress （Poster notice，General）
29.	2015/10/10	Functional analyses of DKK3 in oral squamous cell carcinoma cell lines （Poster notice，General）
30.	2015/10/04	Taurine supplemental therapy in prevention of stroke-like episodes in MELAS
31.	2015/08/08	Myogenic stem cells-derived Sema3A may regulate fiber type of myotubes during muscle regeneration （Poster notice，General）
32.	2014/07/22	Sema3A secreted from satellite cells promotes slow-twitch fiber generation （Poster notice，General）
33.	2013/09/22	Taurine ameliorates mitochondrial dysfunction and prevents stroke-like episodes in patients with MELAS （Poster notice，General）
34.	2013/08/24	Control of skeletal muscle mass by myostatin/TGF-beta signaling （Speech，Panelist at Symposium/Workshop (Appointed)）
35.	2012/12/16	Control of differentiation and morphogenesis by a furin family protease, PC5/6 （Poster notice，General）
36.	2012/09/07	Regulation of caveolin-3 in myogenesis and muscular atrophy through type I TGF-beta receptor kinase. （Poster notice，General）
37.	2012/08/16	Caveolin-3 controls satellite cells and myoblasts through type I TGF-beta receptor kinase （Speech，General）
38.	2012/06/07	Roles of the caveolin-3-transforming gowth factor-beta axis in skeletal myogenesis and muscle atrophy. （Speech，General）
39.	2011/12/02	プロセシング酵素Furinの機能阻害とMyf5陽性筋細胞の動態（Speech）
40.	2011/09/19	Sarcolemmal nNOS prevents muscular wasting in a caveolin-3-deficient limb-girdle muscular dystrophy 1C model （Speech，General）
41.	2011/09/18	Sarcolemmal nNOS prevents muscular wasting in a caveolin-3 deficient limb-girdle muscular dystrophy 1C model. （Speech，General）
42.	2011/09/18	Sarcolemmal nNOS prevents muscular wasting in a caveolin-3-deficient limb-girdle muscular dystrophy 1C model （Poster notice，General）
43.	2011/09/18	Wnt signalling acts as a switch controlling myoblast cell proliferation and differentiation （Poster notice，General）
44.	2011/07/01	Wnt signaling during transition from cell proliferation to differentiation in myoblast cells. （Poster notice，General）
45.	2010/10/14	Reprogrammed fibroblasts as a feasible source of cell-based therapy for muscular dystrophy （Poster notice，General）
46.	2010/07/21	Wound-healing MRL-MpJ phenotype improves outcome of dystrophin deficient mdx mice. （Speech，General）
47.	2010/07/18	Reprogrammed fibroblats are a source of cell therapy for caveolin-3-deficient and laminin α-2-deficient muscular dystrophies （Speech，General）
48.	2010/06/22	Cell-autonomous expression of chordin caused by the injection of Xwnt8 mRNA in early Xenopus embryos. （Poster notice，General）
49.	2009/07/04	Muscle mass regulation by myostatin-signaling related molecules （Speech，Panelist at Symposium/Workshop (Other)）
50.	2009/05/29	Frzb inhibits early Wnt signaling in a cell-autonomous manner in early Xenopus embryos （Poster notice，General）
51.	2008/05/27	Wnt signaling in the endoplasmic reticulum of early Xenopus embryos. （Poster notice，General）
52.	2007/10/17	Myostatin inhibition increases atrogin-1 expression and accelerates skeletal muscle atrophy under denervated conditions. （Poster notice，General）
53.	2006/09/12	PC6, a BMP-3b-processing enzyme, is involved in axial patterning of the Xenopus embryo. （Poster notice，General）
54.	2006/07/24	Wnt3a and Wnt3 during AER formation of chick embryos. （Poster notice，General）
55.	2005/06/28	Characterization of a BMP-3b-processing enzyme in Xenopus embryo. （Poster notice，General）
56.	2003/07/30	BMP-3b and BMP-3 fanction as different dorsalizing factors in Xenopus embryos. （Poster notice，General）
57.	2003/07/12	BMP-3b and cerberus coordinate formation of the Xenopus larval head. （Poster notice，General）
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■ Belonging society

1.	2015/03～	Japan Muscle Society
2.	2015/07～	Japanease Cancer Association