スギヤマ　ヒトシ   杉山　斉    所属   川崎医療短期大学  教育部 医療介護福祉学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Urine Trefoil Factors as Prognostic Biomarkers in Chronic Kidney Disease.
掲載誌名	正式名：BioMed research international 略　 称：Biomed Res Int ISSNコード：23146141
掲載区分	国外
巻・号・頁	2018,pp.3024698
著者・共著者	Yamanari Toshio, Sugiyama Hitoshi, Tanaka Keiko, Morinaga Hiroshi, Kitagawa Masashi, Onishi Akifumi, Ogawa-Akiyama Ayu, Kano Yuzuki, Mise Koki, Ohmoto Yasukazu, Shikata Kenichi, Wada Jun
発行年月	2018
概要	INTRODUCTION:Trefoil factor family (TFF) peptides are increased in serum and urine in patients with chronic kidney disease (CKD). However, whether the levels of TFF predict the progression of CKD remains to be elucidated.METHODS:We determined the TFF levels using peptide-specific ELISA in spot urine samples and performed a prospective cohort study. The association between the levels of urine TFFs and other urine biomarkers as well as the renal prognosis was analyzed in 216 CKD patients (mean age: 53.7 years, 47.7% female, 56.9% with chronic glomerulonephritis, and mean eGFR: 58.5 ml/min/1.73 m2).RESULTS:The urine TFF1 and TFF3 levels significantly increased with the progression of CKD stages, but not the urine TFF2 levels. The TFF1 and TFF3 peptide levels predicted the progression of CKD ≥ stage 3b by ROC analysis (AUC 0.750 and 0.879, resp.); however, TFF3 alone predicted CKD progression in a multivariate logistic regression analysis (odds ratio 3.854, 95% confidence interval 1.316-11.55). The Kaplan-Meier survival curves demonstrated that patients with a higher TFF1 and TFF3 alone, or in combination with macroalbuminuria, had a significantly worse renal prognosis.CONCLUSION:The data suggested that urine TFF peptides are associated with renal progression and the outcomes in patients with CKD.
DOI	10.1155/2018/3024698
PMID	29850501