タケウチ　マサキ   Takeuchi Masaki   竹内　雅貴    所属   川崎医療福祉大学  医療技術学部 臨床検査学科    職種   准教授
言語種別	英語
発表タイトル	Mechanical conditions of nesprin-mediated nucleus-actin filament bindings affect polarized elongation of fibroblasts induced by cyclic stretching
会議名	8th World Congress of Biomechanics
学会区分	国際学会及び海外の学会
発表形式	口頭
講演区分	シンポジウム・ワークショップ パネル（公募）
発表者・共同発表者	◎Naoya Sakamoto, Mai Ogawa, Kiyomi Sadamoto, Masaki Takeuchi, Noriyuki Kataoka
発表年月日	2018/07/10
開催地 （都市, 国名）	Dublin, Ireland
概要	Mechanical signals from external environment of a cell are transmitted to the nucleus from cytoskeletons through LINC (linker of nucleoskeleton and cytoskeleton) complex and are believed to play an important role in cellular morphological and functional responses to stimuli from environments. LINC complex are formed by nesprins and SUN proteins at the nuclear envelope, and nesprin-1 and nesprin-2 are believed to directly bind to actin filament. Previous studies have reported that knockdown of nesprin-1causes suppression of cellular morphological responses to mechanical stimuli, indicating that the nucleus-actin filament bindings are crucial to the morphological responses of cells to mechanical stimuli. To further address the detailed roles of nesprin-medicated nucleus-actin filament bindings, we explored the morphological changes of nesprin-1/-2-depleted fibroblasts exposed to cyclic stretching.