タケウチ　マサキ   Takeuchi Masaki   竹内　雅貴    所属   川崎医療福祉大学  医療技術学部 臨床検査学科    職種   准教授
言語種別	英語
発表タイトル	The early embryogenesis of Polypterus (Bichirs): insights into the origin and evolution of vertebrate body plans
会議名	RIKEN joint retreat 2011
学会区分	全国規模の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎Masaki Takeuchi, Maiko Takahashi, Shinichi Aizawa
発表年月日	2011/01/31
開催地 （都市, 国名）	Kakegawa, Japan
概要	--- As an additional topic, I would like to report about the existence and significance of a homologous bichir gene of siamois/twin, which is the head inducible gene previously found only in amphibian. I named this bichir gene "dioskouroi (dios)" derived from twin gods, Gemini (双子座). In Xenopus embryos, dios have a strong activity of the secondary axis induction as a transcriptional activator similar to siamois. Importantly, dios can rescue the headless phenotype of siamois/twin double knockdown embryos. Dios play a role for the axis organization also in bichir embryos. These results suggest not only that these genes are identified as a functional homolog of each other, but that siamois/dios-related protogene was required for the axis formation in the common ancestor of Osteichthyes.