イシハラ　カツヒコ   Katsuhiko Ishihara   石原　克彦    所属   川崎医療福祉大学  医療福祉マネジメント学部 医療福祉デザイン学科    職種   特任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties.
掲載誌名	正式名：Cell Stem Cell 略　 称：Cell Stem Cell
掲載区分	国外
巻・号・頁	22(3),pp.384-397
著者・共著者	Wakabayashi T, Naito H, Suehiro JI, Lin Y, Kawaji H, Iba T, Kouno T, Ishikawa-Kato S, Furuno M, Takara K, Muramatsu F, Weizhen J, Kidoya H, Ishihara K, Hayashizaki Y, Nishida K, Yoder MC, Takakura N.
発行年月	2018/03
概要	The generation of new blood vessels via angiogenesis is critical for meeting tissue oxygen demands. A role for adult stem cells in this process remains unclear. Here, we identified CD157 (bst1, bone marrow stromal antigen 1) as a marker of tissue-resident vascular endothelial stem cells (VESCs) in large arteries and veins of numerous mouse organs. Single CD157+ VESCs form colonies in vitro and generate donor-derived portal vein, sinusoids, and central vein endothelial cells upon transplantation in the liver. In response to injury, VESCs expand and regenerate entire vasculature structures, supporting the existence of an endothelial hierarchy within blood vessels. Genetic lineage tracing revealed that VESCs maintain large vessels and sinusoids in the normal liver for more than a year, and transplantation of VESCs rescued bleeding phenotypes in a mouse model of hemophilia. Our findings show that tissue-resident VESCs display self-renewal capacity and that vascular regeneration potential exists in peripheral blood vessels.