イシハラ　カツヒコ   Katsuhiko Ishihara   石原　克彦    所属   川崎医療福祉大学  医療福祉マネジメント学部 医療福祉デザイン学科    職種   特任教授
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Infection-Immunity Liaison: Pathogen-driven autoimmune-mimicry (PDAIM).
掲載誌名	正式名：Autoimmunity Reviews
巻・号・頁	13(10),pp.1064-1069
著者・共著者	Saeki Y, Ishihara K
担当区分	最終著者
発行年月	2014/10
概要	Autoimmunity causes pathological conditions resulting in autoimmune diseases (ADs). Although autoimmunity is a mystery, immunological dogma suggests that autoreactive cell reactivation (ACR) breaks self-tolerance and induces autoimmunity. Thus, ACR is a royal pathway for ADs. Cumulative evidence implicates environmental factors as secondary triggers of ADs in the genetically susceptible hosts. Infection is the most likely trigger. Although several mechanisms have been proposed to explain how infectious agents trigger ADs, ACR is assumed to be an essential pathway. Here, by showing some exemplary ADs, we propose two novel pathways, "molecular modification pathway" and "hyper-immune-inflammatory response pathway", which induce AD-like conditions directly by infectious agents without ACR. These AD-like conditions are actually not true "ADs" according to the current definition. Therefore, we define them as "pathogen-driven autoimmune-mimicry (PDAIM)". Confirming PDAIM will open perspectives in developing novel fundamental and non-immunosuppressive therapies for ADs. The idea should also provide novel insights into both the mechanisms of autoimmunity and the pathogenesis of ADs.
DOI	10.1016/j.autrev.2014.08.024