ヤノ ヒロミ   Yano Hiromi
  矢野 博己
   所属   川崎医療福祉大学  医療技術学部 健康体育学科
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells
掲載誌名 正式名:Journal of Immunological Methods
略  称:J Immunol Methods
巻・号・頁 393(1-2),61-69頁
著者・共著者 Masataka Uchida, Eri Oyanagi, Motohiko Miyachi, Akira Yamauchi, Hiromi Yano
発行年月 2013/07
概要 We investigated the effect of macrophage differentiation on the chemotactic activity to invade local damaged myoblasts using in vitro models of muscle injury. We found that: 1) the chemotactic activity of macrophages toward areas of damaged myoblasts might be induced more by live myoblasts than dead ones, 2) the chemotactic activity of macrophages is not due to velocity, but depends on the directionality toward damaged myoblast cells, and 3) macrophage differentiation strongly influence the chemotactic activity toward damaged myoblast cells through the expression of CCR2 and/or F-actin.
DOI 10.1016/j.jim.2013.04.007