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Ju Yong-in
Department Kawasaki University of Medical Welfare , Position Assistant Professor |
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| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | Effect of swimming exercise on three-dimensional trabecular bone microarchitecture in ovariectomized rats |
| Journal | Formal name：Journal of applied physiology Abbreviation：J Appl Physiol ISSN code：00218987 |
| Volume, Issue, Page | 119(9),pp.990-997 |
| Author and coauthor | Yong-In Ju, Teruki Sone, Kazuhiro Ohnaru, Censure Tanaka, Masao Fukunaga |
| Authorship | Lead author,Corresponding author |
| Publication date | 2015/11 |
| Summary | Swimming is generally considered ineffective for increasing bone mass in humans, at least compared with weight-bearing sports. However, swimming exercise has sometimes been shown to have a strong positive effect on bone mass in small animals. This study investigated the effects of swimming on bone mass, strength, and microarchitecture in ovariectomized (OVX) rats. OVX or sham-operations were performed on 18-week-old female Fisher-344 rats. Rats were randomly divided into 4 groups: sham sedentary (Sham-CON); sham swimming-exercised (Sham-SWI); OVX sedentary (OVX-CON); and OVX swimming-exercised (OVX-SWI). Rats in exercise groups performed swimming in a water bath for 60 min/day, 5 days/week, for 12 weeks. Bone mineral density (BMD) in right femurs was analyzed using dual-energy X-ray absorptiometry. Three-dimensional trabecular architecture at the distal femoral metaphysis was analyzed using microcomputed tomography (micro-CT). Geometrical properties of diaphyseal cortical bone were evaluated in the mid-femoral region using micro-CT. The biomechanical properties of femurs were analyzed using 3-point bending. Femoral BMD was significantly decreased following ovariectomy. This change was suppressed by swimming. Trabecular bone thickness, number, and connectivity were decreased by ovariectomy, whereas structure model index (i.e., ratio of rod-like to plate-like trabeculae) increased. These changes were also suppressed by swimming exercise. Femurs displayed greater cortical width and maximum load in SWI groups than in CON groups. Together, these results demonstrate that swimming exercise drastically alleviated both OVX-induced decreases in bone mass and mechanical strength, and the deterioration of trabecular microarchitecture in rat models of osteoporosis. |
| DOI | 10.1152/japplphysiol.00147.2015 |
| PMID | 26338454 |