石本 恭子
   Department     ,
   Position  
Article types 原著
Language English
Peer review Peer reviewed
Title A population-based cross-sectional study of the association between periodontitis and arterial stiffness among the older Japanese population.
Journal Formal name:Journal of periodontal research
Abbreviation:J Periodontal Res
ISSN code:16000765/00223484
Domestic / ForeginForegin
Volume, Issue, Page 0-0頁
Author and coauthor Iwasaki Masanori, Kimura Yumi, Yamaga Takayuki, Yamamoto Naomune, Ishikawa Motonao, Wada Taizo, Sakamoto Ryota, Ishimoto Yasuko, Fujisawa Michiko, Okumiya Kiyohito, Otsuka Kuniaki, Matsubayashi Kozo, Ogawa Hiroshi
Publication date 2020/12
Summary OBJECTIVE:To investigate the potential association between periodontitis and arterial stiffness among the older Japanese population.BACKGROUND:The prevalence of periodontitis is increasing in Japanese older adults. Arterial stiffness increases the risks of cardiovascular events and death, morbidity, and dementia.METHODS:This secondary analysis of data from a cross-sectional study evaluated the periodontal inflamed surface area (PISA), reflecting the amount of inflamed periodontal tissue that was estimated by a full-mouth periodontal examination. Severe periodontitis was defined per the parameters provided by the Centers for Disease Control/American Academy of Periodontology. The Cardio-Ankle Vascular Index (CAVI) was used for measuring the overall stiffness of the artery, and higher CAVI indicated increased arterial stiffness. An ordinal logistic regression model was used to evaluate the association between periodontitis and arterial stiffness.RESULTS:The analysis included 185 Japanese adults [35% men; age, mean (standard deviation) 80.2 (4.4) years]. The average PISA and the prevalence of severe periodontitis were 64.4 mm2 and 27.6%, respectively; 54 (29.2%), 56 (30.3%), and 75 (40.5%) participants were stratified to the CAVI < 9, 9 ≤ CAVI <10, and CAVI ≥ 10 groups, respectively. After adjusting for potential confounders, the odds ratio of the prevalence and severity of arterial stiffness evaluated using CAVI was 1.06 [95% confidence interval (CI) 1.01 to 1.10] for PISA per 10 mm2 and 2.12 (95% CI 1.09 to 4.11) for severe periodontitis.CONCLUSION:Periodontitis was associated with arterial stiffness among Japanese older adults. Further studies are needed to investigate whether arterial stiffness is an intermediate factor in the pathway between periodontitis and systemic diseases, including cardiovascular disease and dementia.
DOI 10.1111/jre.12835
PMID 33368318