石本 恭子
   Department     ,
   Position  
Article types 原著
Language English
Peer review Peer reviewed
Title Periodontitis, periodontal inflammation, and mild cognitive impairment: A 5-year cohort study.
Journal Formal name:Journal of periodontal research
Abbreviation:J Periodontal Res
ISSN code:16000765/00223484
Domestic / ForeginForegin
Volume, Issue, Page 54(3),233-240頁
Author and coauthor Iwasaki Masanori, Kimura Yumi, Ogawa Hiroshi, Yamaga Takayuki, Ansai Toshihiro, Wada Taizo, Sakamoto Ryota, Ishimoto Yasuko, Fujisawa Michiko, Okumiya Kiyohito, Miyazaki Hideo, Matsubayashi Kozo
Publication date 2019/06
Summary BACKGROUND AND OBJECTIVES:Identification of modifiable factors for mild cognitive impairment (MCI) is important since individuals with MCI are at a high risk of dementia and disability. Previous studies have suggested a potential association between periodontitis and cognitive impairment, but the results remain inconclusive. We designed a 5-year longitudinal study to explore the association between MCI and periodontitis and periodontal inflammation in older adults.METHODS:This study included 179 community-dwelling dentate individuals (62 men and 117 women, average age: 80.1 years). A full-mouth periodontal examination at six sites per tooth was performed at baseline. Case definitions provided by the European Workshop in Periodontology Group C (EWP definition) and the Centers for Disease Control/American Academy of Periodontology (CDC/AAP definition) were used to define severe periodontitis. Additionally, the periodontal inflamed surface area (PISA), reflecting the amount of inflamed periodontal tissue, was calculated using clinical periodontal parameters. Follow-up cognitive examinations for MCI diagnosis were performed by neurologists 1, 2, 3, and 5 years after baseline. Odds ratios (ORs) for MCI according to the presence of periodontitis and periodontal inflammation at baseline were calculated using multilevel mixed-effects logistic regression.RESULTS:At baseline, 56.4% and 27.4% of the participants had severe periodontitis by the EWP and CDC/AAP definitions, respectively. After adjusting for follow-up period and other baseline health characteristics (age, sex, smoking status, educational level, physical activity level, obesity, depression, and diabetes), severe periodontitis by either definition was significantly associated with MCI (for the EWP definition: adjusted OR = 3.58, 95% confidence interval [CI] = 1.45-8.87; for the CDC/AAP definition: adjusted OR = 2.61, 95% CI = 1.08-6.28). Periodontal inflammation assessed by PISA was also significantly associated wi
DOI 10.1111/jre.12623
PMID 30345659