イシモト ヤスコ
  石本 恭子
   所属   川崎医療福祉大学  医療技術学部 健康体育学科
   職種   准教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Periodontitis, periodontal inflammation, and mild cognitive impairment: A 5-year cohort study.
掲載誌名 正式名:Journal of periodontal research
略  称:J Periodontal Res
ISSNコード:16000765/00223484
掲載区分国外
巻・号・頁 54(3),233-240頁
著者・共著者 Iwasaki Masanori, Kimura Yumi, Ogawa Hiroshi, Yamaga Takayuki, Ansai Toshihiro, Wada Taizo, Sakamoto Ryota, Ishimoto Yasuko, Fujisawa Michiko, Okumiya Kiyohito, Miyazaki Hideo, Matsubayashi Kozo
発行年月 2019/06
概要 BACKGROUND AND OBJECTIVES:Identification of modifiable factors for mild cognitive impairment (MCI) is important since individuals with MCI are at a high risk of dementia and disability. Previous studies have suggested a potential association between periodontitis and cognitive impairment, but the results remain inconclusive. We designed a 5-year longitudinal study to explore the association between MCI and periodontitis and periodontal inflammation in older adults.METHODS:This study included 179 community-dwelling dentate individuals (62 men and 117 women, average age: 80.1 years). A full-mouth periodontal examination at six sites per tooth was performed at baseline. Case definitions provided by the European Workshop in Periodontology Group C (EWP definition) and the Centers for Disease Control/American Academy of Periodontology (CDC/AAP definition) were used to define severe periodontitis. Additionally, the periodontal inflamed surface area (PISA), reflecting the amount of inflamed periodontal tissue, was calculated using clinical periodontal parameters. Follow-up cognitive examinations for MCI diagnosis were performed by neurologists 1, 2, 3, and 5 years after baseline. Odds ratios (ORs) for MCI according to the presence of periodontitis and periodontal inflammation at baseline were calculated using multilevel mixed-effects logistic regression.RESULTS:At baseline, 56.4% and 27.4% of the participants had severe periodontitis by the EWP and CDC/AAP definitions, respectively. After adjusting for follow-up period and other baseline health characteristics (age, sex, smoking status, educational level, physical activity level, obesity, depression, and diabetes), severe periodontitis by either definition was significantly associated with MCI (for the EWP definition: adjusted OR = 3.58, 95% confidence interval [CI] = 1.45-8.87; for the CDC/AAP definition: adjusted OR = 2.61, 95% CI = 1.08-6.28). Periodontal inflammation assessed by PISA was also significantly associated wi
DOI 10.1111/jre.12623
PMID 30345659