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フジワラ アツシ
Atsushi Fujiwara
藤原 篤之 所属 川崎医療福祉大学 リハビリテーション学部 視能療法学科 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Relationship between progression of visual field damage and choroidal thickness in eyes with normal-tension glaucoma. |
| 掲載誌名 | 正式名：Clinical & experimental ophthalmology 略 称：Clin Exp Ophthalmol ISSNコード：14429071/14426404 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 40(6),pp.576-582 |
| 著者・共著者 | Hirooka Kazuyuki, Fujiwara Atsushi, Shiragami Chieko, Baba Tetsuya, Shiraga Fumio |
| 発行年月 | 2012/08 |
| 概要 | BACKGROUND: To measure choroidal thickness in normal eyes and in patients with normal-tension glaucoma using enhanced depth imaging optical coherence tomography and evaluate the association between choroidal thickness and progression of visual field damage.DESIGN: Cross-sectional comparative study.PARTICIPANTS: A total of 62 eyes of 62 normal subjects and 45 eyes of 45 normal-tension glaucoma patients were examined.METHODS: The choroid was measured at the fovea and 3 mm nasal and temporal from the fovea. In the separate study, both eyes of the patients with normal-tension glaucoma were included in the analyses. Visual fields were measured with automated perimetry. Changes in mean deviation per year (dB/year), that is, mean deviation slope, were calculated.MAIN OUTCOME MEASURES: Difference in the choroidal thickness between the normal subjects and the patients with normal-tension glaucoma. The relationship between mean deviation slope and the choroidal thickness in eyes with normal-tension glaucoma was analysed.RESULTS: Compared with normal subjects, the choroidal thickness was significantly thinner in eyes with normal-tension glaucoma at 3 mm nasal from the fovea (P = 0.02). There was a significant correlation between the choroidal thickness at 3 mm nasal from the fovea and the mean deviation slope (Pearson's r = 0.413; P < 0.001).CONCLUSION: The decrease in the thickness of the choroid at 3 mm nasal from the fovea in eyes with normal-tension glaucoma may be associated with progressive visual field loss. Thus, choroidal abnormalities may play a role in the pathogenesis of normal-tension glaucoma. |
| DOI | 10.1111/j.1442-9071.2012.02762.x |
| PMID | 22300430 |