Mitsuru Shiota
   Department   Kawasaki University of Medical Welfare  ,
   Position   Professor with Special Assignment
Article types 原著
Language English
Peer review Peer reviewed
Title Vasohibin-1 Is a Poor Prognostic Factor of Ovarian Carcinoma.
Journal Formal name：The Tohoku journal of experimental medicine
Abbreviation：Tohoku J Exp Med
ISSN code：13493329/00408727
Domestic / ForeginForegin
Volume, Issue, Page 243(2),pp.107-114
Author and coauthor Sano Rikiya, Kanomata Naoki, Suzuki Soichiro, Shimoya Koichiro, Sato Yasufumi, Moriya Takuya, Shiota Mitsuru
Authorship Last author
Publication date 2017/10
Summary Vasohibin-1 (VASH1) is an identified negative feedback inhibitor of angiogenesis induced by vascular endothelial growth factor (VEGF) in vascular endothelial cells (ECs). Expression of VASH1 has been reported not only in ECs of normal tissue, but also in ECs surrounding malignant tumors. In malignant tumors, VASH1 is also gaining attention as a prognosis prediction marker. The aim of this study is to investigate the correlation between VASH1 expression and vascular-related factors and various clinicopathological outcomes in clinical cases of ovarian carcinoma. We retrospectively analyzed clinical records of 58 patients with ovarian carcinoma. The expression patterns of VASH1 and other vascular-related factors (CD31 as markers of microvessel density (MVD), VEGF receptor type 2 (VEGFR2), D2-40 as markers of lymphovessel density), and Ki67 (as proliferation markers of cancer cells) were examined immunohistochemically. We studied the correlation between immunohistochemical expression and overall survival. VASH1 expression pattern significantly differed between Federation of Obstetrics and Gynecology (FIGO) Stages. Numbers of VASH1-positive vessels had a significant positive correlation with MVD (Speaman's correlation coefficient (ρ) was 0.51, p < 0.001), VEGFR2-positive vessels (ρ = 0.61, p < 0.001), and percentage of Ki67 (ρ = 0.28, p = 0.034). The Cox univariable analyses revealed that the group of high VASH1 expression (> 14.6 vessels per mm2) at Stages I-III is a prognostic factor (HR = 3.3, 95%CI = 0.4-8.4; p = 0.013). Our results indicate that VASH1 expression in ovarian carcinoma is significantly associated with vascular-related factors and Ki67 expression. We propose that VASH1 is a prognostic marker in ovarian carcinoma.
DOI 10.1620/tjem.243.107
PMID 29057763