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ミヤタ ジュンヤ
Miyata Junya
宮田 潤也 所属 川崎医療福祉大学 医療技術学部 診療放射線技術学科 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Dosimetric comparison of pencil beam scanning proton therapy with or without multi-leaf collimator versus volumetric-modulated arc therapy for treatment of malignant glioma. |
| 掲載誌名 | 正式名：Medical dosimetry : official journal of the American Association of Medical Dosimetrists 略 称：Med Dosim ISSNコード：18734022/18734022 |
| 掲載区分 | 国外 |
| 著者・共著者 | Junya Miyata, Yuki Tominaga, Kazuto Kondo, Yasuaki Sonoda, Hideki Hanazawa, Mami Sakai, Satoshi Itasaka, Masataka Oita, Masahiro Kuroda |
| 発行年月 | 2023/03 |
| 概要 | This study aimed to examine the dosimetric effect of intensity-modulated proton therapy (IMPT) with a multi-leaf collimator (MLC) in treating malignant glioma. We compared the dose distribution of IMPT with or without MLC (IMPTMLC+ or IMPTMLC-, respectively) using pencil beam scanning and volumetric-modulated arc therapy (VMAT) in simultaneous integrated boost (SIB) plans for 16 patients with malignant gliomas. High- and low-risk target volumes were assessed using D2%, V90%, V95%, homogeneity index (HI), and conformity index (CI). Organs at risk (OARs) were evaluated using the average dose (Dmean) and D2%. Furthermore, the dose to the normal brain was evaluated using from V5Gy to V40Gy at 5 Gy intervals. There were no significant differences among all techniques regarding V90%, V95%, and CI for the targets. HI and D2% for IMPTMLC+ and IMPTMLC- were significantly superior to those for VMAT (p < 0.01). The Dmean and D2% of all OARs for IMPTMLC+ were equivalent or superior to those of other techniques. Regarding the normal brain, there was no significant difference in V40Gy among all techniques whereas V5Gy to V35Gy in IMPTMLC+ were significantly smaller than those in IMPTMLC- (with differences ranging from 0.45% to 4.80%, p < 0.05) and VMAT (with differences ranging from 6.85% to 57.94%, p < 0.01). IMPTMLC+ could reduce the dose to OARs, while maintaining target coverage compared to IMPTMLC- and VMAT in treating malignant glioma. |
| DOI | 10.1016/j.meddos.2023.01.008 |
| PMID | 36914455 |