オカワキ　マコト   Makoto Okawaki   岡脇　誠    所属   川崎医科大学  医学部 臨床医学　先端腫瘍医学    職種   講師
言語種別	日本語
発表タイトル	神経内分泌腫瘍に対するHsp90阻害剤の抗腫瘍効果
会議名	第71回日本癌学会学術総会
学会区分	全国規模の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎山村真弘, 平井敏弘, 濃野勉, 岡脇誠, 弘中克治, 山口佳之
発表年月日	2012/09/20
開催地 （都市, 国名）	札幌
学会抄録	第71回日本癌学会学術総会抄録集 337
概要	Heat shock protein（Hsp90） has numerous cellular functions, including promotion of proper protein folding, and stabilizes a number of oncogenic proteins, many of which are overexpressed in cancers. The objective of this study is to evaluate an antitumor effect of Hsp90 inhibitor, called 17-AAG, in neuroendocrine tumor （NET） cell lines. NET cell line （COLO320） was treated with Hsp90 inhibitor, 17-AAG, to examine the effect on proliferation of NET cells by using the WST-1 proliferation assay. 17-AAG inhibited cell proliferation in NET cells in a dose- and time-dependent manner. 17-AAG was also effective to induce apoptosis in NET cells as determined with FACS analysis and immunochemistry. The Hsp90 inhibitor is useful as an antitumor drug in NET, inhibiting the proliferation of NET cells through novel mechanism.