Makoto Okawaki
   Department     Kawasaki Medical School, Department of Clinical Oncology,
   Position   Assistant Professor
Language English
Title Wnt signaling involved in gastrointestinal neuroendocrine tumors.
Conference WNT2011
Conference Type International society and overseas society
Presentation Type Poster notice
Lecture Type General
Publisher and common publisher◎Yamamura Masahiro, Nohno Tsutomu, Hirai Toshihiro, Okawaki Makoto, Hironaka Katsuji, Yamaguchi Yoshiyuki
Date 2011/07/01
Venue
(city and name of the country)
LA, USA
Society abstract WNT2011 Abstract Book 44
Summary Background: Wnt/beta-catenin signaling is known to play an important role in metastatic and invasive phenotypes in many tumor including colon cancer. We studied here the relationship between Wnt signaling and pathological profiles in neuroendocrine tumors from patients. Methods: We evaluated immunohistochemically the subcellular localization of beta-catenin in a total 33 gastrointestinal neuroendocrine tumors including 13 gastric NETs and 20 rectal NETs. Expression of Ki-67 and the other marker proteins was examined with immunohistochemical staining in comparison with beta-catenin expression in NET, aimed at evaluating the prognostic value of these markers.
Result: All cases demonstrated membranous and cytoplasmic staining of beta-catenin. Nuclear accumulation of beta-catenin was frequently detected in 24 of 33 (72.7%), although there is significant correlation with rectal NETs. Nuclear accumulation of beta-catenin was correlated with the proliferative marker Ki-67 (MIB-1) labeling index and poor prognosis in rectal NETs.
Conclusion: Our findings suggest that nuclear accumulation of beta-catenin may be involved in proliferative activity and prognostic factor of rectal NET.