オカワキ　マコト   Makoto Okawaki   岡脇　誠    所属   川崎医科大学  医学部 臨床医学　先端腫瘍医学    職種   講師
言語種別	英語
発表タイトル	Wnt signaling involved in gastrointestinal neuroendocrine tumors.
会議名	WNT2011
学会区分	国際学会及び海外の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎Yamamura Masahiro, Nohno Tsutomu, Hirai Toshihiro, Okawaki Makoto, Hironaka Katsuji, Yamaguchi Yoshiyuki
発表年月日	2011/07/01
開催地 （都市, 国名）	LA, USA
学会抄録	WNT2011 Abstract Book 44
概要	Background: Wnt/beta-catenin signaling is known to play an important role in metastatic and invasive phenotypes in many tumor including colon cancer. We studied here the relationship between Wnt signaling and pathological profiles in neuroendocrine tumors from patients. Methods: We evaluated immunohistochemically the subcellular localization of beta-catenin in a total 33 gastrointestinal neuroendocrine tumors including 13 gastric NETs and 20 rectal NETs. Expression of Ki-67 and the other marker proteins was examined with immunohistochemical staining in comparison with beta-catenin expression in NET, aimed at evaluating the prognostic value of these markers. Result: All cases demonstrated membranous and cytoplasmic staining of beta-catenin. Nuclear accumulation of beta-catenin was frequently detected in 24 of 33 (72.7%), although there is significant correlation with rectal NETs. Nuclear accumulation of beta-catenin was correlated with the proliferative marker Ki-67 (MIB-1) labeling index and poor prognosis in rectal NETs. Conclusion: Our findings suggest that nuclear accumulation of beta-catenin may be involved in proliferative activity and prognostic factor of rectal NET.