ヤマウチ　アキラ   Akira Yamauchi   山内　明    所属   川崎医科大学  医学部 基礎医学　生化学    職種   教授
言語種別	英語
発表タイトル	Discovery of Pyrazole-based Anti-cancer Compounds via Cell-based Drug Discovery
会議名	The 82nd Annual Meeting of Japan Cancer Association
主催者	Japan Cancer Association
学会区分	全国規模の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	Yamauchi A, Okamoto S, Choshi T, Katase N, Tomonobu N, Kinoshita R, Sakaguchi M, Yamamura M.
発表年月日	2023/09/23
国名	日本
開催地 （都市, 国名）	横浜
開催期間	2023/09/21～2023/09/23
概要	The development of new drugs for cancer therapy is a crucial topic for improving the lives of cancer patients. Wepreviously discovered a new compound 14-100 which showed an inhibition of pancreatic cancer cell dynamics despiteminimal cytotoxicity, using a Cell-based Drug Discovery approach. This compound inhibited the growth of pancreaticcancer as well as metastasis in vivo using a mouse orthotopic xenograft model. Compound 14-100 is a pyrazole-basedcompound. Recently, we synthesized analogues of Compound 14-100 and evaluated the eff ect on pancreatic cancer celldynamics. We found that at least 18 compounds inhibited cell dynamics (Biomedicine & Pharmacotherapy 155 (2022)113733). Compound 14-100 and its analogues, discovered through a Cell-based Drug Discovery approach, have shownpromising activity against pancreatic cancer, and may represent a new class of drug candidates for this disease.
researchmap用URL	https://www.c-linkage.co.jp/jca2023/index.html