Akira Yamauchi    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Biochemistry,    Position   Professor
Language	English
Title	Comparing effects of small molecular weight compounds on proliferation and chemotaxis of pancreatic cancer cells
Conference	American Association for Cancer Research (AACR) Annual Meeting 2019
Promoters	American Association for Cancer Research (AACR)
Conference Type	International society and overseas society
Presentation Type	Poster notice
Lecture Type	General
Publisher and common publisher	Yamamura M, Yamauchi A, Katase N, Sakaguchi M, Katata Y, Tanioka H, Okawaki M, Nagasaka T, Yamaguchi Y.
Date	2019/04/01
Venue (city and name of the country)	Atlanta, Georgia, USA
Summary	Background & Aims: The new therapy for pancreatic cancer which has the poorest prognosis among malignant tumors is high demand nowadays. The overall 5-year survival rate in all stages of this type of cancer is less than 5%, even with the multimodality therapy, including surgery, chemotherapy and radiotherapy. Although gemcitabine (GEM) is a key drug in the treatment of advanced pancreatic cancer, the therapeutic effect is limited because of drug resistance. Heat shock protein 90 (HSP90) is known to be overexpressed in several types of cancer cells, and its inhibition has shown promise in the treatment of solid malignancies. Src kinases work as a signal switch for multiple molecular signal transduction pathways. The objective of this study is to evaluate an antitumor effect of three kinds of small molecular weight compounds (antimetabolite Gemcitabine, HSP90 inhibitor NVP-AUY922, and Src kinase inhibitor Dasatinib) on tumor growth and chemotaxis in pancreatic cancer cell lines.