ヤマウチ アキラ
  山内 明
   所属   川崎医科大学  医学部 基礎医学 生化学
   職種   教授
言語種別 英語
発表タイトル Comparing effects of small molecular weight compounds on proliferation and chemotaxis of pancreatic cancer cells
会議名 American Association for Cancer Research (AACR) Annual Meeting 2019
主催者 American Association for Cancer Research (AACR)
学会区分 国際学会及び海外の学会
発表形式 ポスター掲示
講演区分 一般
発表者・共同発表者Yamamura M, Yamauchi A, Katase N, Sakaguchi M, Katata Y, Tanioka H, Okawaki M, Nagasaka T, Yamaguchi Y.
発表年月日 2019/04/01
開催地
(都市, 国名)
Atlanta, Georgia, USA
概要 Background & Aims: The new therapy for pancreatic cancer which has the poorest prognosis among malignant tumors is high demand nowadays. The overall 5-year survival rate in all stages of this type of cancer is less than 5%, even with the multimodality therapy, including surgery, chemotherapy and radiotherapy. Although gemcitabine (GEM) is a key drug in the treatment of advanced pancreatic cancer, the therapeutic effect is limited because of drug resistance. Heat shock protein 90 (HSP90) is known to be overexpressed in several types of cancer cells, and its inhibition has shown promise in the treatment of solid malignancies. Src kinases work as a signal switch for multiple molecular signal transduction pathways. The objective of this study is to evaluate an antitumor effect of three kinds of small molecular weight compounds (antimetabolite Gemcitabine, HSP90 inhibitor NVP-AUY922, and Src kinase inhibitor Dasatinib) on tumor growth and chemotaxis in pancreatic cancer cell lines.