Takeshi Nagasaka
   Department     Kawasaki Medical School, Department of Clinical Oncology,
   Position   Associate Professor
Language English
Title Comparing effects of small molecular weight compounds on proliferation and chemotaxis of pancreatic cancer cells
Conference American Association for Cancer Research (AACR) Annual Meeting 2019
Promoters American Association for Cancer Research (AACR)
Conference Type International society and overseas society
Presentation Type Poster notice
Lecture Type General
Publisher and common publisherYamamura M, Yamauchi A, Katase N, Sakaguchi M, Katata Y, Tanioka H, Okawaki M, Nagasaka T, Yamaguchi Y.
Date 2019/04/01
(city and name of the country)
Atlanta, Georgia, USA
Summary Background & Aims: The new therapy for pancreatic cancer which has the poorest prognosis among malignant tumors is high demand nowadays. The overall 5-year survival rate in all stages of this type of cancer is less than 5%, even with the multimodality therapy, including surgery, chemotherapy and radiotherapy. Although gemcitabine (GEM) is a key drug in the treatment of advanced pancreatic cancer, the therapeutic effect is limited because of drug resistance. Heat shock protein 90 (HSP90) is known to be overexpressed in several types of cancer cells, and its inhibition has shown promise in the treatment of solid malignancies. Src kinases work as a signal switch for multiple molecular signal transduction pathways. The objective of this study is to evaluate an antitumor effect of three kinds of small molecular weight compounds (antimetabolite Gemcitabine, HSP90 inhibitor NVP-AUY922, and Src kinase inhibitor Dasatinib) on tumor growth and chemotaxis in pancreatic cancer cell lines.