Tamaki Sasaki
   Department     ,
Article types 原著
Language English
Peer review Peer reviewed
Title Expression of the fibroblast growth factor receptor 1-4 genes in glomeruli in anti-Thy1.1 mesangial proliferative glomerulonephritis.
Journal Formal name:Virchows Archiv : an international journal of pathology
Abbreviation:Virchows Arch
ISSN code:09456317
Volume, Issue, Page 435(5),501-508頁
Author and coauthor Jyo-Oshiro Yoshiyuki, Sasaki Tamaki, Kawakami Yasuhiko, Nohno Tsutomu, Itoh Nobuyuki, Osawa Gengo, Kashihara Naoki
Publication date 1999/11
Summary Basic fibroblast growth factor (FGF2) is generally known to induce proliferation of cultured mesangial cells and is expressed in proliferative mesangial cells in anti-Thy1.1 mesangial proliferative glomerulonephritis (anti-Thy1.1 GN). The distribution of the FGF receptor (FGFR) has not been studied in anti-Thy1.1 GN, so we used in situ hybridization to determine whether cells expressing FGFR1-4 mRNAs could be detected. In normal rats, all glomeruli were negative for FGFR1-4 mRNA, but those of the mesangial proliferative phase expressed FGFR1-4 mRNA in proliferative mesangial cells. Proliferation of mesangial cells has not been observed in normal rats injected with FGF2 but it has been noted in anti-Thy1.1 rats injected with FGF2. These data and our results demonstrate that mesangial cells produce and release FGF2 after injury and that during the proliferative phase these cells upregulate FGFR in vivo. This study is the first to demonstrate expression of FGFR1-4, mRNAs in pathological glomeruli of anti-Thy1.1 GN. The FGF2 and FGFR1-4 genes were expressed in the proliferative mesangial cells. Upregulation of FGFR is necessary for mesangial proliferation by FGF2.
DOI 10.1007/s004280050434
Document No. 10592054