オオシロ ヨシユキ   Oshiro Yoshiyuki
  大城 義之
   所属   川崎医科大学  医学部 臨床医学 総合内科学3
   職種   准教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Expression of the fibroblast growth factor receptor 1-4 genes in glomeruli in anti-Thy1.1 mesangial proliferative glomerulonephritis.
掲載誌名 正式名:Virchows Archiv : an international journal of pathology
略  称:Virchows Arch
ISSNコード:09456317
巻・号・頁 435(5),501-508頁
著者・共著者 Jyo-Oshiro Yoshiyuki, Sasaki Tamaki, Kawakami Yasuhiko, Nohno Tsutomu, Itoh Nobuyuki, Osawa Gengo, Kashihara Naoki
発行年月 1999/11
概要 Basic fibroblast growth factor (FGF2) is generally known to induce proliferation of cultured mesangial cells and is expressed in proliferative mesangial cells in anti-Thy1.1 mesangial proliferative glomerulonephritis (anti-Thy1.1 GN). The distribution of the FGF receptor (FGFR) has not been studied in anti-Thy1.1 GN, so we used in situ hybridization to determine whether cells expressing FGFR1-4 mRNAs could be detected. In normal rats, all glomeruli were negative for FGFR1-4 mRNA, but those of the mesangial proliferative phase expressed FGFR1-4 mRNA in proliferative mesangial cells. Proliferation of mesangial cells has not been observed in normal rats injected with FGF2 but it has been noted in anti-Thy1.1 rats injected with FGF2. These data and our results demonstrate that mesangial cells produce and release FGF2 after injury and that during the proliferative phase these cells upregulate FGFR in vivo. This study is the first to demonstrate expression of FGFR1-4, mRNAs in pathological glomeruli of anti-Thy1.1 GN. The FGF2 and FGFR1-4 genes were expressed in the proliferative mesangial cells. Upregulation of FGFR is necessary for mesangial proliferation by FGF2.
DOI 10.1007/s004280050434
文献番号 10592054