ニシマツ　シンイチロウ   Shinichiro Nishimatsu   西松　伸一郎    所属   川崎医科大学  医学部 一般教養　自然科学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Wnt10a is involved in AER formation during chick limb development.
掲載誌名	正式名：Developmental dynamics : an official publication of the American Association of Anatomists 略　 称：Dev Dyn ISSNコード：10588388
巻・号・頁	233(2),pp.282-287
著者・共著者	Narita Tomohiro, Sasaoka Shunsuke, Udagawa Kiyoshi, Ohyama Takahiro, Wada Naoyuki, Nishimatsu Shin-ichiro, Takada Shinji, Nohno Tsutomu
発行年月	2005/06
概要	The apical ectodermal ridge (AER) is indispensable for vertebrate limb development and requires Wnt/beta-catenin signaling for induction and maintenance. We report identification and involvement of Wnt10a in AER formation during chick limb development. Chicken Wnt10a has 82% identity with mouse Wnt10a in the amino acid sequence. The Wnt10a gene was expressed broadly in the surface ectoderm from as early as stage 10. By stage 15, the expression was restricted to the surface ectoderm overlying the lateral plate mesoderm. Wnt10a expression became intensified in the presumptive limb ectoderm during AER formation, and subsequently intense expression signals persisted in the AER. Wnt10a misexpression led to ectopic Fgf8 expression in the developing limb ectoderm and induced translocation of beta-catenin in chick embryo fibroblasts. These results suggest that Wnt10a is involved in AER formation in the chick limb bud through the Wnt/beta-catenin signaling pathway.
DOI	10.1002/dvdy.20321
文献番号	15789446