Shinichiro Nishimatsu    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Natural Sciences,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Comparison of DNA sequences on VZV glycoproteins of the Oka vaccine and parental Oka strains.
Journal	Formal name：International Pediatrics Abbreviation：Int. Pediatrics ISSN code：8856256
Volume, Issue, Page	17(3),pp.158-163
Author and coauthor	Niizuma Takahiro, Terada Kihei, Kataoka Naoki, Nishimatsu Shin-ichiro, Nohno Tsutomu
Publication date	2002
Summary	The Oka vaccine strain induces immunity against the varicellazoster virus (VZV) without clinical manifestations. However, the molecular basis of virulence in VZV is not known. VZV glycoproteins induce cellular and humoral immunity against VZV after infection. To investigate the molecular basis of viral attenuation and distinguish the Oka vaccine strain from the wild strains, we compared the DNA sequences of seven glycoproteins between the Oka vaccine and the parental Oka strains. The DNA sequences in gE, gB, gH, gl, gC, gL and gK of the Oka vaccine strain were completely consistent with those of the parental Oka strain. The Oka vaccine strain induced immunity level similar to the parental Oka strain. One-point mutation was detected at the stop-codon of gC in the Oka vaccine strain. This could be useful for distinguishing the Oka vaccine strain from the parental Oka strain by DNA sequence analysis.