ニシマツ　シンイチロウ   Shinichiro Nishimatsu   西松　伸一郎    所属   川崎医科大学  医学部 一般教養　自然科学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Comparison of DNA sequences on VZV glycoproteins of the Oka vaccine and parental Oka strains.
掲載誌名	正式名：International Pediatrics 略　 称：Int. Pediatrics ISSNコード：8856256
巻・号・頁	17(3),pp.158-163
著者・共著者	Niizuma Takahiro, Terada Kihei, Kataoka Naoki, Nishimatsu Shin-ichiro, Nohno Tsutomu
発行年月	2002
概要	The Oka vaccine strain induces immunity against the varicellazoster virus (VZV) without clinical manifestations. However, the molecular basis of virulence in VZV is not known. VZV glycoproteins induce cellular and humoral immunity against VZV after infection. To investigate the molecular basis of viral attenuation and distinguish the Oka vaccine strain from the wild strains, we compared the DNA sequences of seven glycoproteins between the Oka vaccine and the parental Oka strains. The DNA sequences in gE, gB, gH, gl, gC, gL and gK of the Oka vaccine strain were completely consistent with those of the parental Oka strain. The Oka vaccine strain induced immunity level similar to the parental Oka strain. One-point mutation was detected at the stop-codon of gC in the Oka vaccine strain. This could be useful for distinguishing the Oka vaccine strain from the parental Oka strain by DNA sequence analysis.