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Shinichiro Nishimatsu
Department Kawasaki Medical School Kawasaki Medical School, Department of Natural Sciences, Position Professor |
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| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | Ventral mesoderm induction and patterning by bone morphogenetic protein heterodimers in Xenopus embryos. |
| Journal | Formal name：Mechanisms of development Abbreviation：Mech Dev ISSN code：09254773/18726356 |
| Volume, Issue, Page | 74(1-2),pp.75-88 |
| Author and coauthor | Nishimatsu Shin-ichiro, Thomsen Gerald H |
| Authorship | Lead author |
| Publication date | 1998/06 |
| Summary | Bone morphogenetic proteins (BMPs) perform diverse functions in vertebrate development. Here we demonstrate that the heterodimeric BMP-4/7 protein directly induces ventral mesoderm and blood in Xenopus animal caps, and BMP-2/7 heterodimers may function similarly. We also provide indirect evidence that BMP heterodimers function in embryos, using assays with dominant-negative BMP ligands. Homodimeric BMP-2 and BMP-4 proteins do not induce mesoderm, but they ventralize mesoderm induction by activin. In contrast, BMP-7 protein interferes with mesoderm induction by activin, but BMP-7 stimulates ventral mesoderm induction by the heterodimer, BMP-4/7. This novel property of BMP-7 distinguishes it from other BMPs. BMP-7 may therefore function in early embryogenesis to antagonize activin signals and potentiate BMP signals. We propose that BMP heterodimers convey signals for ventral mesoderm induction and patterning in Xenopus development. |
| DOI | 10.1016/S0925-4773(98)00070-7 |
| Document No. | 9651485 |