Shinichiro Nishimatsu    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Natural Sciences,    Position   Professor
Article types	総説
Language	English
Peer review	Peer reviewed
Title	Activin as a cell differentiation factor.
Journal	Formal name：Progress in growth factor research Abbreviation：Prog Growth Factor Res ISSN code：09552235
Volume, Issue, Page	2(2),pp.113-124
Author and coauthor	Ueno Naoto, Nishimatsu Shin-ichiro, Murakami Kazuo
Authorship	2nd author
Publication date	1990
Summary	Activin, originally discovered as a polypeptide hormone that is capable of stimulating follicle-stimulating hormone secretion from pituitary cells in vitro, has recently been found to have a much wider range of biological activities. There are a number of reports of activin action as a cell differentiation factor on various types of cells rather than as a modulator of hormone secretion, as predicted initially, based on its structural similarity to transforming growth factor-beta. Studies of the distribution of activin and its receptor in a variety of tissues and its wide-ranging actions clearly illustrates its multifunctional properties. In particular, activin has been shown to be a potential regulator of early development of Xenopus laevis. Observation of activin effect in embryogenesis is of general importance to our understanding of the role of the family of growth factors in developmental processes.
DOI	10.1016/0955-2235(90)90027-H
Document No.	1966558