ニシマツ　シンイチロウ   Shinichiro Nishimatsu   西松　伸一郎    所属   川崎医科大学  医学部 一般教養　自然科学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia.
掲載誌名	正式名：The Journal of biological chemistry 略　 称：J Biol Chem ISSNコード：00219258/1083351X
巻・号・頁	270(32),pp.18719-18722
著者・共著者	Sugaya Takeshi, Nishimatsu Shin-ichiro, Tanimoto Keiji, Takimoto Eriko, Yamagishi Toshiyuki, Imamura Kenkichi, Goto Saori, Imaizumi Kazunori, Hisada Yutaka, Otsuka Akio, Uchida Hiromi, Sugiura Masaki, Fukuta Katsuhiro, Fukamizu Akiyoshi, Murakami Kazuo
担当区分	2nd著者
発行年月	1995/08
概要	Angiotensin (AT) II, the bioactive octapeptide in the renin-angiotensin system that plays a key role in cardiovascular homeostasis, exerts its multiple effects through the different types of AT receptors, AT1a, AT1b, and AT2. Previously, we showed chronic hypotension in angiotensinogen (the precursor of AT)-deficient mice and a dramatic increase in renin mRNA levels in its kidney, but it remains unclear which types of AT receptors regulate the blood pressure and renin gene expression. In order to elucidate the physiological roles of AT1a receptor, we generated mutant mice with a targeted replacement of the AT1a receptor loci by the lacZ gene. In the heterozygous mutant mice, the strong lacZ staining was found in the glomerulus and juxtaglomerular apparatus of the renal cortex, which coincided with that of the signals detected by in situ hybridization. Chronic hypotension was observed in the heterozygous and homozygous mutant mice, with 10 and 22 mm Hg lower systolic blood pressure, respectively, than that of wild-type littermates. Both the levels of renin mRNA in the kidney and plasma renin activity were markedly increased only in the homozygous mutant mice. These results demonstrated that an AT1a-mediated signal transduction pathway is, at least in part, involved in the regulation of blood pressure and renin gene expression.
DOI	10.1074/jbc.270.32.18719
文献番号	7642517