ニシマツ　シンイチロウ   Shinichiro Nishimatsu   西松　伸一郎    所属   川崎医科大学  医学部 一般教養　自然科学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Heart formative factor(s) is localized in the anterior endoderm of early Xenopus neurula.
掲載誌名	正式名：Roux's Archives of Developmental Biology ISSNコード：0930035X
巻・号・頁	205(5-6),pp.282-289
著者・共著者	Tonegawa A, Moriya M, Tada M, Nishimatsu S, Katagiri C, Ueno N.
発行年月	1996
概要	To elucidate the mechanisms of early heart morphogenesis in Xenopus laevis, we examined the effect of endoderm on heart morphogenesis in the early Xenopus neurula. Explants of anterior ventral (presumptive heart) mesoderm from early neurula were cultured alone or in combination with endoderm dissected from various regions. Heart formation was scored by an original heart index based on morphology. These explant studies revealed that anterior ventral endoderm plays a critical role in heart morphogenesis. Furthermore, we found that it was possible to confer this heart-forming ability on posterior ventral endoderm by the injection of poly(A)+ RNA from stage 13 anterior endoderm. These results imply that the heart formative factor(s) is localized in the anterior endoderm of the early neurula and that at least part of this activity is encoded by mRNA(s).
DOI	10.1007/BF00365806