Shinichiro Nishimatsu    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Natural Sciences,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis.
Journal	Formal name：Proceedings of the National Academy of Sciences of the United States of America Abbreviation：Proc Natl Acad Sci U S A ISSN code：00278424/10916490
Volume, Issue, Page	88(15),pp.6511-6514
Author and coauthor	Asashima Makoto, Nakano Hiroshi, Uchiyama Hideho, Sugino Hiromu, Nakamura Takanori, Eto Yuzuru, Ejima Daisuke, Nishimatsu Shin-ichiro, Ueno Naoto, Kinoshita Kei
Publication date	1991/08
Summary	Activin A, a member of the transforming growth factor beta superfamily, has recently been found to have potent mesoderm-inducing activity on isolated early Xenopus animal-cap cells. We measured the activin activity of the Xenopus egg extract by using an erythroid-differentiating test with Friend leukemia cells. The results showed that an activin homologue is, indeed, contained in unfertilized eggs and blastulae of Xenopus laevis in a considerable amount. This activity was eluted at the same retention time as human activin A when fractionated by reversed-phase HPLC. Furthermore, the fraction containing erythroid-differentiating factor activity had mesoderm-inducing activity on Xenopus animal-cap cells. The mesoderm-inducing activity of this fraction was suppressed when coincubated with follistatin, an activin-binding protein. These results suggest that an endogenous activin may be a natural mesoderm-inducing factor acting in Xenopus embryogenesis.
DOI	10.1073/pnas.88.15.6511
Document No.	1862079