Shinichiro Nishimatsu    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Natural Sciences,    Position   Professor
Article types	総説
Language	English
Peer review	Peer reviewed
Title	Diurnal regulation of per repeat family in the suprachiasmatic nucleus of rat brain.
Journal	Formal name：Neuroscience and biobehavioral reviews Abbreviation：Neurosci Biobehav Rev ISSN code：01497634
Volume, Issue, Page	18(4),pp.571-577
Author and coauthor	Ishida Nori, Nishimatsu Shin-ichiro, Matsui Miwa, Mitsui Youji, Nohno Tsutomu, Shibata Naoki, Noji Sumihare
Authorship	2nd author
Publication date	1994
Summary	We have recently reported fluctuations in the expression of the period repeat sequence, pp2.5, during light-dark cycles in the suprachiasmatic nucleus (SCN) of rat. Presently, we performed in situ hybridization which shows that the fluctuation of pp2.5 expression continues during constant darkness conditions in the SCN of rat. The light exposure during subjective night but not subjective day triggered its elevated expression in a time- dependent manner which is parallel to that of c-fos expression. In this review, the cloning and characterization of multiple per repeat sequences from mouse genom and rat brain mRNA were summarized. The abundance or a novel per repeat mRNA (designated as RB15) fluctuates during a light-dark cycle in the SCN. These findings suggest that per repeat sequence may have a role for the mammalian circadian rhythms. The evolutionary relationship between the mammarian per repeat sequence and the Drosophila period gene is also discussed.
Document No.	7708371