Shinichiro Nishimatsu    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Natural Sciences,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Expression of bone morphogenetic protein-5 gene during chick heart development: possible roles in valvuloseptal endocardial cushion formation.
Journal	Formal name：The Anatomical record Abbreviation：Anat Rec ISSN code：0003276X/10970185
Volume, Issue, Page	264(4),pp.313-316
Author and coauthor	Yamagishi Toshiyuki, Nakajima Yuji, Nishimatsu Shin-ichiro, Nohno Tsutomu, Ando Katsumi, Nakamura Hiroaki
Publication date	2001/12
Summary	The bone morphogenetic protein (BMP) family, comprising multifunctional peptide growth factors, regulates many developmental processes in a variety of tissues. We examined the spatiotemporal expression of BMP5 by in situ hybridization in chick embryonic hearts from stages 5 to 33. The BMP5 gene was first expressed in the endoderm underlying the precardiac mesoderm at stages 5 to 8. Thereafter, BMP5 expression was restricted to the myocardium of the atrioventricular (AV) canal and outflow tract (OT) regions, where the valvuloseptal endocardial cushion tissue is induced. These results suggest that BMP5 may play important roles not only in myocardial differentiation, but also in the formation and maintenance of endocardial cushion tissue.
DOI	10.1002/ar.10013
Document No.	11745086