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Hideho Wada
Department Kawasaki Medical School Kawasaki Medical School, Department of Hematology, Position Professor |
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| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | A follow up study on false-positive preoperative HIV test results |
| Journal | Formal name：Health Science Journal Abbreviation：Health Sci J. ISSN code：1791-809X |
| Domestic / Foregin | Foregin |
| Publisher | iMedPub Journals |
| Volume, Issue, Page | 14(3),pp.1-5 |
| Author and coauthor | Nakagiri Itsuhiro, Wada Hideho |
| Authorship | Last author |
| Publication date | 2020/06 |
| Summary | In this research we followed up 31,041 HIV screening test results using immunochromatography assaya to investigate the incidence of false-positive test results and the time duration within which false positives continued to be produced. Of the 31,041 cases reviewed, 13 cases returned a false positive result upon initial screening, and were retested, using the same assay, at least twice over 3 years. The patients ranged in age from 12 to 89 years, with a median age of 68 years, and the male:female ratio was 4:9 The time from the first medical examination to the second assessment ranged from 89 to 519 days, with an average of 239.7 days. Of the 13 cases, four produced false-positive results for the p24 antigen, and nine were false-positive for the HIV antibody. Five individuals continued to produce false-positive results on further investigation, while eight presented negative results. The five cases with persistent false-positive results included a tendon sheath incision enforcement case, in which the false-positive antibody reaction persisted for 883 days, and an intraocular lens insertion case in which the false-positive reaction persisted for 800 days. The individual metabolic characteristics of the patients may contribute to the false-positive HIV result persisting long term. The HIV test results of eight cases were negative after the initial false-positive results. We hypothesize that a nonspecific product was produced through the interaction between a therapeutic drug and the patient's metabolism to produce transient false-positive reactions. These eight cases were reassessed at an average of 298 days after the first false-positive results, and the nonspecific product produced temporarily might have disappeared within this time. If preoperative HIV screening test is carried out before the therapeutic drugs have taken effect, the number of false-positive reactions may be reduced. |
| DOI | 10.36648/1791-809X.14.2.713 |
| Document No. | 1791-809X-14-713 |