Hironobu Katsuyama    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Public Health,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Changes in gene expression level for defense system enzymes against oxidative stress and glutathione level in rat administered paraquat.
Journal	Formal name：International journal of molecular medicine Abbreviation：Int J Mol Med ISSN code：11073756/1791244X
Volume, Issue, Page	15(4),pp.689-693
Author and coauthor	Tomita Masafumi, Katsuyama Hironobu, Okuyama Toshiko, Hidaka Kazuo, Minatogawa Yohsuke
Authorship	2nd author
Publication date	2005/04
Summary	We examined the effect of PQ on the relative levels of gene expression of antioxidant enzymes and glutathione (GSH) status in lungs of rats exposed to 20 mg/kg PQ. At 16 h after PQ intake, the mRNA expression level of glutathione reductase (GR) showed the greatest increase, and those of catalase (CAT) and manganese-superoxide dismutase (MnSOD) showed more modest increases. In contrast, PQ had little or no effect on the levels of mRNAs for copper/zinc-superoxide dismutase (CuZnSOD) and glutathione peroxidase (GPX).
Document No.	15754033