カツヤマ　ヒロノブ   Hironobu Katsuyama   勝山　博信    所属   川崎医科大学  医学部 臨床医学　公衆衛生学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Changes in gene expression level for defense system enzymes against oxidative stress and glutathione level in rat administered paraquat.
掲載誌名	正式名：International journal of molecular medicine 略　 称：Int J Mol Med ISSNコード：11073756/1791244X
巻・号・頁	15(4),pp.689-693
著者・共著者	Tomita Masafumi, Katsuyama Hironobu, Okuyama Toshiko, Hidaka Kazuo, Minatogawa Yohsuke
担当区分	2nd著者
発行年月	2005/04
概要	We examined the effect of PQ on the relative levels of gene expression of antioxidant enzymes and glutathione (GSH) status in lungs of rats exposed to 20 mg/kg PQ. At 16 h after PQ intake, the mRNA expression level of glutathione reductase (GR) showed the greatest increase, and those of catalase (CAT) and manganese-superoxide dismutase (MnSOD) showed more modest increases. In contrast, PQ had little or no effect on the levels of mRNAs for copper/zinc-superoxide dismutase (CuZnSOD) and glutathione peroxidase (GPX).
文献番号	15754033