Tsutomu Tamada    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Radiology, Division of Diagnostic Radiology,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Hepatic parenchymal enhancement at Gd-EOB-DTPA enhanced MR imaging - Correlation with morphological grading of severity in cirrhosis and chronic hepatitis
Journal	Formal name：Magnetic resonance imaging Abbreviation：Magn Reson Imaging ISSN code：0730725X
Volume, Issue, Page	30(3),pp.356-360
Author and coauthor	Kanki Akihiko, Ito Katsuyoshi, Tamada Tsutomu, Higashi Hiroki, Higaki Atsushi, Sato Tomohiro, Noda Yasufumi, Tanimoto Daigo, Yamamoto Akira
Publication date	2012/04
Summary	The aim was to clarify whether enhancement effects of the liver parenchyma in the hepatobiliary phase (HP) of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging were correlated with the morphological grading of the severity in cirrhosis. A total of 62 patients with chronic hepatitis or cirrhosis underwent Gd-EOB-DTPA-enhanced MR imaging. Relative enhancement (RE) of liver parenchyma was calculated from signal intensity (SI) measurements obtained at precontrast images (SIpre) and 20-min postcontrast HP images (SIpost) as: (SIpost-SIpre)/SIpre. Morphological MR grades of severity in cirrhosis were divided into four groups. Then, RE of liver parenchyma and morphologic MR grading were correlated. Regarding the morphologic severity of cirrhosis, the numbers of patients with MR grade 1, 2, 3 and 4 were 14 (23%), 7 (11%), 28 (45%) and 13 (21%), respectively. The mean REs of liver parenchyma in each group of MR morphologic grade 1, 2, 3 and 4 were 0.71±0.21, 0.62±0.16, 0.70±0.22 and 0.77±0.18, respectively. There was no significant correlation between the MR grading of morphologic severity and the RE of liver parenchyma at 20-min HP. Hepatic parenchymal enhancement in the HP of Gd-EOB-DTPA-enhanced MR imaging did not necessarily decrease according to the severity of morphologic changes in cirrhosis. This fact may suggest that the hepatic uptake of Gd-EOB-DTPA depends on the preserved hepatocytes function rather than the severity of morphologic changes in cirrhosis.