テラワキ セイゴウ   Seigo Terawaki
  寺脇 正剛
   所属   川崎医科大学  医学部 基礎医学 分子遺伝医学
   職種   特任講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages.
掲載誌名 正式名:Royal Society open science
略  称:R Soc Open Sci
ISSNコード:20545703/20545703
掲載区分国外
巻・号・頁 8(7),202333頁
著者・共著者 Valečka Jan, Camosseto Voahirana, McEwan David G, Terawaki Seigo, Liu Zhuangzhuang, Strock Eva, Almeida Catarina R, Su Bing, Dikic Ivan, Liang Yinming, Gatti Evelina, Pierre Philippe
発行年月 2021/07
概要 We report here that RUFY4, a newly characterized member of the 'RUN and FYVE domain-containing' family of proteins previously associated with autophagy enhancement, is highly expressed in alveolar macrophages (AM). We show that RUFY4 interacts with mitochondria upon stimulation by microbial-associated molecular patterns of AM and dendritic cells. RUFY4 interaction with mitochondria and other organelles is dependent on a previously uncharacterized OmpH domain located immediately upstream of its C-terminal FYVE domain. Further, we demonstrate that rufy4 messenger RNA can be translated from an alternative translation initiation codon, giving rise to a N-terminally truncated form of the molecule lacking most of its RUN domain and with enhanced potential for its interaction with mitochondria. Our observations point towards a role of RUFY4 in selective mitochondria clearance in activated phagocytes.
DOI 10.1098/rsos.202333
PMID 34295519