テラワキ　セイゴウ   Seigo Terawaki   寺脇　正剛    所属   川崎医科大学  医学部 基礎医学　分子遺伝医学    職種   特任講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice.
掲載誌名	正式名：Inflammation research : official journal of the European Histamine Research Society ... [et al.] 略　 称：Inflamm Res ISSNコード：1420908X/10233830
掲載区分	国外
巻・号・頁	70(5),pp.539-541
著者・共著者	Iwasaki Naruhito, Terawaki Seigo, Shimizu Kouhei, Oikawa Daisuke, Sakamoto Hirokazu, Sunami Kishiko, Tokunaga Fuminori
発行年月	2021/05
概要	OBJECTIVE:Histamine derived from mast cells and basophils plays important roles in inducing allergic symptoms. Although T cells also produce histamine, the involvement of the histamine produced from T cells has remained enigmatic. We sought to reveal the roles of T helper 2 (Th2) cell-derived histamine in nasal allergic disorders.METHODS:The histamine production from Th2 cells was measured by EIA. The mRNA expression of histidine decarboxylase (HDC) was measured by real-time PCR. To investigate the roles of Th2 cell-derived histamine in vivo, we analyzed an antigen-specific Th2 cell transfer mouse model.RESULTS:Th2 cells produced histamine by T cell receptor stimulation, and these properties were specific for Th2 cells, but not Th1 cells and naïve CD4 T cells. The histamine produced from Th2 cells was involved in the infiltrations of Th2 cells in response to antigen exposure.CONCLUSION:These results suggest that Th2 cell-derived histamine play important roles in nasal allergic disorders.
DOI	10.1007/s00011-021-01458-x
PMID	33811487