Seigo Terawaki    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Molecular and Genetic Medicine,    Position   Assistant Professor with Special Assignment
Article types	総説
Language	English
Peer review	Non peer reviewed
Title	RUFY4: Immunity piggybacking on autophagy?
Journal	Formal name：Autophagy Abbreviation：Autophagy ISSN code：15548635/15548627
Domestic / Foregin	Foregin
Volume, Issue, Page	12(3),pp.598-600
Author and coauthor	Terawaki Seigo, Camosseto Voahirana, Pierre Philippe, Gatti Evelina
Authorship	Lead author
Publication date	2016/07/13
Summary	Although autophagy is a highly conserved mechanism among species and cell types, few are the molecules involved with the autophagic process that display cell- or tissue- specific expression. We have unraveled the positive regulatory role on autophagy of RUFY4 (RUN and FYVE domain containing 4), which is expressed in subsets of immune cells, including dendritic cells (DCs). DCs orchestrate the eradication of pathogens by coordinating the action of the different cell types involved in microbe recognition and destruction during the immune response. To fulfill this function, DC display particular regulation of their endocytic and autophagy pathways in response to the immune environment. Autophagy flux is downmodulated in DCs upon microbe sensing, but is remarkably augmented, when cells are differentiated in the presence of the pleiotropic cytokine IL4 (interleukin 4). From gene expression studies aimed at comparing the impact of IL4 on DC differentiation, we identified RUFY4, as a novel regulator that augments autophagy flux and, when overexpressed, induces drastic membrane redistribution and strongly tethers lysosomes. RUFY4 is therefore one of the few known positive regulators of autophagy that is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma.
DOI	10.1080/15548627.2015.1136772
PMID	26760128