テラワキ セイゴウ   Seigo Terawaki
  寺脇 正剛
   所属   川崎医科大学  医学部 基礎医学 分子遺伝医学
   職種   特任講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 PD-1 inhibits antiviral immunity at the effector phase in the liver.
掲載誌名 正式名:The Journal of experimental medicine
略  称:J Exp Med
ISSNコード:00221007/00221007
掲載区分国外
巻・号・頁 198(1),39-50頁
著者・共著者 Iwai Yoshiko, Terawaki Seigo, Ikegawa Masaya, Okazaki Taku, Honjo Tasuku
発行年月 2003/07
概要 Unlike naive T cells, effector T cells can be activated by either T cell receptor signal or costimulatory signal alone and therefore the absence of costimulatory molecules on tissue cells cannot explain the tolerance mechanism at the effector phase. Here we report that PD-L1, the ligand for the immunoinhibitory receptor PD-1, was expressed on vascular endothelium in peripheral tissues. Liver nonparenchymal cells including sinusoidal endothelial cells and Kupffer cells constitutively expressed PD-L1 and inhibited proliferation and cell division of activated T cells expressing PD-1. The absence of PD-1 induced proliferation of effector T cells in the adenovirus-infected liver and resulted in rapid clearance of the virus. These results indicate that PD-1 plays an important role in T cell tolerance at the effector phase and the blockade of the PD-1 pathway can augment antiviral immunity.
DOI 10.1084/jem.20022235
PMID 12847136