テラワキ　セイゴウ   Seigo Terawaki   寺脇　正剛    所属   川崎医科大学  医学部 基礎医学　分子遺伝医学    職種   特任講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	PD-1 inhibits antiviral immunity at the effector phase in the liver.
掲載誌名	正式名：The Journal of experimental medicine 略　 称：J Exp Med ISSNコード：00221007/00221007
掲載区分	国外
巻・号・頁	198(1),pp.39-50
著者・共著者	Iwai Yoshiko, Terawaki Seigo, Ikegawa Masaya, Okazaki Taku, Honjo Tasuku
担当区分	2nd著者
発行年月	2003/07
概要	Unlike naive T cells, effector T cells can be activated by either T cell receptor signal or costimulatory signal alone and therefore the absence of costimulatory molecules on tissue cells cannot explain the tolerance mechanism at the effector phase. Here we report that PD-L1, the ligand for the immunoinhibitory receptor PD-1, was expressed on vascular endothelium in peripheral tissues. Liver nonparenchymal cells including sinusoidal endothelial cells and Kupffer cells constitutively expressed PD-L1 and inhibited proliferation and cell division of activated T cells expressing PD-1. The absence of PD-1 induced proliferation of effector T cells in the adenovirus-infected liver and resulted in rapid clearance of the virus. These results indicate that PD-1 plays an important role in T cell tolerance at the effector phase and the blockade of the PD-1 pathway can augment antiviral immunity.
DOI	10.1084/jem.20022235
PMID	12847136