|
Seigo Terawaki
Department Kawasaki Medical School Kawasaki Medical School, Department of Molecular and Genetic Medicine, Position Assistant Professor with Special Assignment |
|
| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. |
| Journal | Formal name：Immunity Abbreviation：Immunity ISSN code：10747613/10747613 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 17(1),pp.31-40 |
| Author and coauthor | Fukuyama Satoshi, Hiroi Takachika, Yokota Yoshifumi, Rennert Paul D, Yanagita Manabu, Kinoshita Naotoshi, Terawaki Seigo, Shikina Takashi, Yamamoto Masafumi, Kurono Yuichi, Kiyono Hiroshi |
| Publication date | 2002/07 |
| Summary | Initiation of nasopharyngeal-associated lymphoid tissue (NALT) development is independent of the programmed cytokine cascade necessary for the formation of Peyer's patches (PP) and peripheral lymph nodes (PLN), a cytokine cascade which consists of IL-7R, LTalpha1beta2/LTbetaR, and NIK. However, the subsequent organization of NALT seems to be controlled by these cytokine signaling cascades since the maturation of NALT structure is generally incomplete in those cytokine cascade-deficient mice. NALT as well as PP and PLN are completely absent in Id2(-/-) mice. NALT organogenesis is initiated following the adoptive transfer of CD3(-)CD4(+)CD45(+) cells into Id2(-/-) mice, constituting direct evidence that CD3(-)CD4(+)CD45(+) inducer cells can provide an IL-7R-, LTalpha1beta2/LTbetaR-, and NIK-independent tissue organogenesis pathway for secondary lymphoid tissue development. |
| DOI | 10.1016/s1074-7613(02)00339-4 |
| PMID | 12150889 |