Ken Sugimoto    Department   Kawasaki Medical School  Kawasaki Medical School, Department of General Geriatric Medicine,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy.
Journal	Formal name：American journal of physiology. Heart and circulatory physiology Abbreviation：Am J Physiol Heart Circ Physiol ISSN code：03636135/03636135
Domestic / Foregin	Foregin
Volume, Issue, Page	293(6),pp.H3396-H3403
Author and coauthor	Nakano Noritsugu, Hori Hisae, Abe Minako, Shibata Hiroki, Arimura Takuro, Sasaoka Taishi, Sawabe Motoji, Chida Kouji, Arai Tomio, Nakahara Ken-ichi, Kubo Toru, Sugimoto Ken, Katsuya Tomohiro, Ogihara Toshio, Doi Yoshinori, Izumi Tohru, Kimura Akinori
Publication date	2007/12
Summary	Elevated wall stress by hypertension induces an adaptive myocardial hypertrophy via releasing prohypertrophic hormones such as angiotensin II. In this study, we investigated the involvement of bone morphogenetic protein-10 (BMP10) in hypertension-induced cardiac hypertrophy. Expression of BMP10 was increased in the hypertrophied ventricles from hypertensive rats. BMP10 localized on cell surface and at stretch-sensing Z disc of cardiomyocytes, where BMP10 interacted with a protein called titin-cap (Tcap). A rare variant of the human BMP10 gene, Thr326Ile, was found to be associated with hypertensive dilated cardiomyopathy. The variant BMP10 demonstrated decreased binding to Tcap and increased extracellular secretion. Conditioned medium from cells transfected with wild-type or variant BMP10 induced hypertrophy in rat neonatal cardiomyocytes, except that medium from variant BMP10-carrying cells showed an enhanced effect reflecting the increased secretion. These observations suggested that hypertension induced expression of prohypertrophic BMP10, and the hypertrophic effect of BMP10 was modulated, at least in part, by its binding to Tcap at the Z disc.
DOI	10.1152/ajpheart.00311.2007
PMID	17921333