スギモト　ケン   Ken Sugimoto   杉本　研    所属   川崎医科大学  医学部 臨床医学　総合老年医学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy.
掲載誌名	正式名：American journal of physiology. Heart and circulatory physiology 略　 称：Am J Physiol Heart Circ Physiol ISSNコード：03636135/03636135
掲載区分	国外
巻・号・頁	293(6),pp.H3396-H3403
著者・共著者	Nakano Noritsugu, Hori Hisae, Abe Minako, Shibata Hiroki, Arimura Takuro, Sasaoka Taishi, Sawabe Motoji, Chida Kouji, Arai Tomio, Nakahara Ken-ichi, Kubo Toru, Sugimoto Ken, Katsuya Tomohiro, Ogihara Toshio, Doi Yoshinori, Izumi Tohru, Kimura Akinori
発行年月	2007/12
概要	Elevated wall stress by hypertension induces an adaptive myocardial hypertrophy via releasing prohypertrophic hormones such as angiotensin II. In this study, we investigated the involvement of bone morphogenetic protein-10 (BMP10) in hypertension-induced cardiac hypertrophy. Expression of BMP10 was increased in the hypertrophied ventricles from hypertensive rats. BMP10 localized on cell surface and at stretch-sensing Z disc of cardiomyocytes, where BMP10 interacted with a protein called titin-cap (Tcap). A rare variant of the human BMP10 gene, Thr326Ile, was found to be associated with hypertensive dilated cardiomyopathy. The variant BMP10 demonstrated decreased binding to Tcap and increased extracellular secretion. Conditioned medium from cells transfected with wild-type or variant BMP10 induced hypertrophy in rat neonatal cardiomyocytes, except that medium from variant BMP10-carrying cells showed an enhanced effect reflecting the increased secretion. These observations suggested that hypertension induced expression of prohypertrophic BMP10, and the hypertrophic effect of BMP10 was modulated, at least in part, by its binding to Tcap at the Z disc.
DOI	10.1152/ajpheart.00311.2007
PMID	17921333