Ken Sugimoto
Department Kawasaki Medical School Kawasaki Medical School, Department of General Geriatric Medicine, Position Professor |
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Article types | 原著 |
Language | English |
Peer review | Peer reviewed |
Title | Intravenous nicorandil in conjunction with coronary reperfusion therapy is associated with better clinical and functional outcomes in patients with acute myocardial infarction. |
Journal | Formal name:Circulation journal : official journal of the Japanese Circulation Society Abbreviation:Circ J ISSN code:13469843/13469843 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 67(4),pp.295-300 |
Author and coauthor | Sugimoto Ken, Ito Hiroshi, Iwakura Katsuomi, Ikushima Masashi, Kato Akinobu, Kimura Ryusuke, Tanaka Koji, Masuyama Tohru, Ogihara Toshio, Kawano Shigeo, Fujii Kenshi |
Publication date | 2003/04 |
Summary | The aim of this retrospective study was to assess whether intravenous nicorandil, a hybrid of NO and a KATP channel opener, in conjunction with percutaneous coronary intervention (PCI) improves the long-term prognosis in patients with acute myocardial infarction (AMI). Intravenous nicorandil has already been shown to improve the in-hospital prognosis of patients with anterior AMI. The study population consisted of 272 patients with a reperfused AMI who were admitted during a similar time interval, before (control; n=114) and after nicorandil treatment (n=158). In the nicorandil group, a 4 mg bolus injection was given, followed by 6 mg/h infusion for 24 h and then oral nicorandil at 15 mg/day for at least 1 month. In the patients with an anterior AMI, left ventricular (LV) function was better and the frequency of LV remodeling was lower after 3 months in the nicorandil group; however, in those with a non-anterior AMI, there were no differences in functional outcome and the frequency of LV remodeling between the 2 groups. The frequency of cardiac events was significantly lower in the nicorandil group, and the use of nicorandil was derived as a potential factor related to freedom from cardiac events (p<0.01, odds ratio = 0.27). Nicorandil treatment was associated with better myocardial perfusion and a better functional and clinical outcome than PCI alone, and this beneficial effect was maintained for a long time, particularly in patients with anterior AMI. |
DOI | 10.1253/circj.67.295 |
PMID | 12655158 |